{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sieminska I"],"funding":["Horizon 2020 Framework Programme"],"pagination":["862416"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9289201"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12"],"pubmed_abstract":["Prostate cancer (PC) is the second most often diagnosed malignancy in men and one of the major causes of cancer death worldwide. Despite genetic predispositions, environmental factors, including a high-fat diet, obesity, a sedentary lifestyle, infections of the prostate, and exposure to chemicals or ionizing radiation, play a crucial role in PC development. Moreover, due to a lack of, or insufficient T-cell infiltration and its immunosuppressive microenvironment, PC is frequently classified as a \"cold\" tumor. This is related to the absence of tumor-associated antigens, the lack of T-cell activation and their homing into the tumor bed, and the presence of immunological cells with regulatory functions, including myeloid-derived suppressor cells (MDSCs), regulatory T cells (Treg), and tumor-a"],"journal":["Frontiers in oncology"],"pubmed_title":["Myeloid-Derived Suppressor Cells as Key Players and Promising Therapy Targets in Prostate Cancer."],"pmcid":["PMC9289201"],"funding_grant_id":["GA 777682"],"pubmed_authors":["Sieminska I","Baran J"],"additional_accession":[]},"is_claimable":false,"name":"Myeloid-Derived Suppressor Cells as Key Players and Promising Therapy Targets in Prostate Cancer.","description":"Prostate cancer (PC) is the second most often diagnosed malignancy in men and one of the major causes of cancer death worldwide. Despite genetic predispositions, environmental factors, including a high-fat diet, obesity, a sedentary lifestyle, infections of the prostate, and exposure to chemicals or ionizing radiation, play a crucial role in PC development. Moreover, due to a lack of, or insufficient T-cell infiltration and its immunosuppressive microenvironment, PC is frequently classified as a \"cold\" tumor. This is related to the absence of tumor-associated antigens, the lack of T-cell activation and their homing into the tumor bed, and the presence of immunological cells with regulatory functions, including myeloid-derived suppressor cells (MDSCs), regulatory T cells (Treg), and tumor-a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-29T10:40:19.491Z","creation":"2025-02-19T02:43:37.984Z"},"accession":"S-EPMC9289201","cross_references":{"pubmed":["35860573"],"doi":["10.3389/fonc.2022.862416"]}}