biostudies-literatureSieminska IHorizon 2020 Framework Programme862416https://www.ebi.ac.uk/biostudies/studies/S-EPMC9289201biostudies-literatureUnknown12Prostate cancer (PC) is the second most often diagnosed malignancy in men and one of the major causes of cancer death worldwide. Despite genetic predispositions, environmental factors, including a high-fat diet, obesity, a sedentary lifestyle, infections of the prostate, and exposure to chemicals or ionizing radiation, play a crucial role in PC development. Moreover, due to a lack of, or insufficient T-cell infiltration and its immunosuppressive microenvironment, PC is frequently classified as a "cold" tumor. This is related to the absence of tumor-associated antigens, the lack of T-cell activation and their homing into the tumor bed, and the presence of immunological cells with regulatory functions, including myeloid-derived suppressor cells (MDSCs), regulatory T cells (Treg), and tumor-aFrontiers in oncologyMyeloid-Derived Suppressor Cells as Key Players and Promising Therapy Targets in Prostate Cancer.PMC9289201GA 777682Sieminska IBaran JfalseMyeloid-Derived Suppressor Cells as Key Players and Promising Therapy Targets in Prostate Cancer.Prostate cancer (PC) is the second most often diagnosed malignancy in men and one of the major causes of cancer death worldwide. Despite genetic predispositions, environmental factors, including a high-fat diet, obesity, a sedentary lifestyle, infections of the prostate, and exposure to chemicals or ionizing radiation, play a crucial role in PC development. Moreover, due to a lack of, or insufficient T-cell infiltration and its immunosuppressive microenvironment, PC is frequently classified as a "cold" tumor. This is related to the absence of tumor-associated antigens, the lack of T-cell activation and their homing into the tumor bed, and the presence of immunological cells with regulatory functions, including myeloid-derived suppressor cells (MDSCs), regulatory T cells (Treg), and tumor-a2022-01-01T00:00:00Z20222025-04-29T10:40:19.491Z2025-02-19T02:43:37.984ZS-EPMC92892013586057310.3389/fonc.2022.862416