{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Viurcos-Sanabria R"],"funding":["Consejo Nacional de Ciencia y Tecnología"],"pubmed_abstract":["The contribution of the cellular immune response to the severity of coronavirus disease 2019 (COVID-19) is still uncertain because most evidence comes from patients receiving multiple drugs able to change immune function. Herein, we conducted a prospective cohort study and obtained blood samples from 128 unvaccinated healthy volunteers to examine the <i>in vitro</i> response pattern of CD4+ and CD8+ T cells and monocyte subsets to polyclonal stimuli, including anti-CD3, anti-CD28, poly I:C, severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) recombinant spike S1 protein, and lipopolysaccharide. Then, we started a six-month follow-up and registered 12 participants who got SARS-CoV-2 infection, from whom we retrospectively analyzed the basal immune response pattern of T cells a"],"journal":["Frontiers in immunology"],"pagination":["897995"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9289744"],"repository":["biostudies-literature"],"pubmed_title":["<i>In Vitro</i> Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19."],"pmcid":["PMC9289744"],"pubmed_authors":["Viurcos-Sanabria R","Viurcos-Sanabria V","Rizo-Tellez SA","Escobedo G","Rodriguez-Cortes O","Manjarrez-Reyna AN","Flores-Mejia R","Arroyo-Valerio A","Gonzalez-Chavez A","Mendez-Garcia LA","Leon-Pedroza JI","Solleiro-Villavicencio H","Carrillo-Ruiz JD","Gonzalez-Sanabria J"],"additional_accession":[]},"is_claimable":false,"name":"<i>In Vitro</i> Exposure of Primary Human T Cells and Monocytes to Polyclonal Stimuli Reveals a Basal Susceptibility to Display an Impaired Cellular Immune Response and Develop Severe COVID-19.","description":"The contribution of the cellular immune response to the severity of coronavirus disease 2019 (COVID-19) is still uncertain because most evidence comes from patients receiving multiple drugs able to change immune function. Herein, we conducted a prospective cohort study and obtained blood samples from 128 unvaccinated healthy volunteers to examine the <i>in vitro</i> response pattern of CD4+ and CD8+ T cells and monocyte subsets to polyclonal stimuli, including anti-CD3, anti-CD28, poly I:C, severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) recombinant spike S1 protein, and lipopolysaccharide. Then, we started a six-month follow-up and registered 12 participants who got SARS-CoV-2 infection, from whom we retrospectively analyzed the basal immune response pattern of T cells a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-08-30T03:13:30.151Z","creation":"2022-08-09T06:00:32.526Z"},"accession":"S-EPMC9289744","cross_references":{"pubmed":["35860236"],"doi":["10.3389/fimmu.2022.897995"]}}