{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nguyen M"],"funding":["Ministry of Health and Welfare","Chonnam National University","National Research Foundation of Korea"],"pagination":["1131-1136"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9290037"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(7)"],"pubmed_abstract":["On the basis of the previously reported polypharmacological profile of truncated d-1'-homologated adenosine derivatives [J. Med. Chem.2020, 63, 16012], the l-nucleoside analogues were synthesized using computer-aided design and evaluated for biological activity. The target molecules were synthesized from d-ribose via the key intramolecular cyclization of the monotosylate and Mitsunobu condensation. The peroxisome proliferator-activated receptor (PPAR) binding activities of l-nucleoside analogue <b>2d</b> (<i>K</i> <sub>i</sub> = 4.3 μM for PPARγ and 1.0 μM for PPARδ) were significantly improved in comparison with those of the d-nucleoside compound <b>1</b> (11.9 and 2.7 μM, respectively). In addition, the l-nucleosides showed more potent adiponectin-secretion-promoting activity than the d-"],"journal":["ACS medicinal chemistry letters"],"pubmed_title":["Design, Synthesis, and Biological Activity of l-1'-Homologated Adenosine Derivatives."],"pmcid":["PMC9290037"],"funding_grant_id":["2021-2440","NRF-2022R1I1A3056585","NRF-2019R1F1A1063905","HI20C0079","NRF-2019R1A2C2085749"],"pubmed_authors":["Nguyen Y","Kim G","Choi H","Jeong LS","Pham L","Noh M","Hyun YE","Kim JA","Nguyen M","An S"],"additional_accession":[]},"is_claimable":false,"name":"Design, Synthesis, and Biological Activity of l-1'-Homologated Adenosine Derivatives.","description":"On the basis of the previously reported polypharmacological profile of truncated d-1'-homologated adenosine derivatives [J. Med. Chem.2020, 63, 16012], the l-nucleoside analogues were synthesized using computer-aided design and evaluated for biological activity. The target molecules were synthesized from d-ribose via the key intramolecular cyclization of the monotosylate and Mitsunobu condensation. The peroxisome proliferator-activated receptor (PPAR) binding activities of l-nucleoside analogue <b>2d</b> (<i>K</i> <sub>i</sub> = 4.3 μM for PPARγ and 1.0 μM for PPARδ) were significantly improved in comparison with those of the d-nucleoside compound <b>1</b> (11.9 and 2.7 μM, respectively). In addition, the l-nucleosides showed more potent adiponectin-secretion-promoting activity than the d-","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-05-28T01:23:16.771Z","creation":"2025-04-07T10:19:38.201Z"},"accession":"S-EPMC9290037","cross_references":{"pubmed":["35859875"],"doi":["10.1021/acsmedchemlett.2c00159"]}}