{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Edwards SD"],"funding":["National Eye Institute","NIBIB NIH HHS","NEI NIH HHS","Office of Experimental Program to Stimulate Competitive Research","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["2786-2794"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9290187"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(6)"],"pubmed_abstract":["Injectable hydrogels have previously demonstrated potential as a temporary scaffold for tissue regeneration or as a delivery vehicle for cells, growth factors, or drugs. However, most injectable hydrogel systems lack a microporous structure, preventing host cell migration into the hydrogel interior and limiting spreading and proliferation of encapsulated cells. Herein, an injectable microporous hydrogel assembled from gelatin/gelatin methacryloyl (GelMA) composite microgels is described. Microgels are produced by a water-in-oil emulsion using a gelatin/GelMA aqueous mixture. These microgels show improved thermal stability compared to GelMA-only microgels and benefit from combined photopolymerization using UV irradiation (365 nm) in the presence of a photoinitiator (PI) and enzymatic reacti"],"journal":["ACS applied bio materials"],"pubmed_title":["Fast-Curing Injectable Microporous Hydrogel for <i>In Situ</i> Cell Encapsulation."],"pmcid":["PMC9290187"],"funding_grant_id":["OIA-1757371","R21 EB032134","1R21EY02795301","P20 GM113131","R21 EY027953","P20GM113131"],"pubmed_authors":["Brown JM","Jeong KJ","Edwards SD","Kim YJ","Boudreau RD","Hou S","Lee Y"],"additional_accession":[]},"is_claimable":false,"name":"Fast-Curing Injectable Microporous Hydrogel for <i>In Situ</i> Cell Encapsulation.","description":"Injectable hydrogels have previously demonstrated potential as a temporary scaffold for tissue regeneration or as a delivery vehicle for cells, growth factors, or drugs. However, most injectable hydrogel systems lack a microporous structure, preventing host cell migration into the hydrogel interior and limiting spreading and proliferation of encapsulated cells. Herein, an injectable microporous hydrogel assembled from gelatin/gelatin methacryloyl (GelMA) composite microgels is described. Microgels are produced by a water-in-oil emulsion using a gelatin/GelMA aqueous mixture. These microgels show improved thermal stability compared to GelMA-only microgels and benefit from combined photopolymerization using UV irradiation (365 nm) in the presence of a photoinitiator (PI) and enzymatic reacti","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-22T02:01:10.673Z","creation":"2025-04-05T20:12:02.763Z"},"accession":"S-EPMC9290187","cross_references":{"pubmed":["35576622"],"doi":["10.1021/acsabm.2c00214"]}}