biostudies-literatureMaier GSwiss National Science FoundationEuropean Research CouncilUniversität BaselSystemsX.ch769-796https://www.ebi.ac.uk/biostudies/studies/S-EPMC9290843biostudies-literatureUnknown600(4)<h4>Key points</h4>Maximal endurance performance is greater in the early daytime. Timed exercise differentially alters the muscle transcriptome and (phospho)-proteome. Early daytime exercise triggers energy provisioning and tissue regeneration. Early night-time exercise activates stress-related and catabolic pathways. Scheduled training has limited effects on the muscle and liver circadian clocks.<h4>Abstract</h4>Timed physical activity might potentiate the health benefits of training. The underlying signalling events triggered by exercise at different times of day are, however, poorly understood. Here, we found that time-dependent variations in maximal treadmill exercise capacity of naïve mice were associated with energy stores, mostly hepatic glycogen levels. Importantly, running at diffThe Journal of physiologyTranscriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and zeitgeber activity of training in mouse muscle.PMC9290843616830Delezie JMaier GSantos GRitz DHandschin CWestermark POfalseTranscriptomic, proteomic and phosphoproteomic underpinnings of daily exercise performance and zeitgeber activity of training in mouse muscle.<h4>Key points</h4>Maximal endurance performance is greater in the early daytime. Timed exercise differentially alters the muscle transcriptome and (phospho)-proteome. Early daytime exercise triggers energy provisioning and tissue regeneration. Early night-time exercise activates stress-related and catabolic pathways. Scheduled training has limited effects on the muscle and liver circadian clocks.<h4>Abstract</h4>Timed physical activity might potentiate the health benefits of training. The underlying signalling events triggered by exercise at different times of day are, however, poorly understood. Here, we found that time-dependent variations in maximal treadmill exercise capacity of naïve mice were associated with energy stores, mostly hepatic glycogen levels. Importantly, running at diff2022-01-01T00:00:00Z2022 Feb2026-07-14T16:20:50.689Z2022-08-05T07:04:06.367ZS-EPMC92908433414271710.1113/JP281535