{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Liu M"],"funding":["China Scholarship Council","Nutricia Research B.V., Utrecht, the Netherlands","China Scholarship Council (CSC)"],"pagination":["137-148"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9291823"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["52(1)"],"pubmed_abstract":["<h4>Background</h4>Two to four percentage of infants are affected by cow's milk allergy (CMA), which persists in 20% of cases. Intervention approaches using early oral exposure to cow's milk protein or hydrolysed cow's milk formula are being studied for CMA prevention. Yet, concerns regarding safety and/or efficacy remain to be tackled in particular for high-risk non-exclusively breastfed infants. Therefore, safe and effective strategies to improve early life oral tolerance induction may be considered.<h4>Objective</h4>We aim to investigate the efficacy of CMA prevention using oral pre-exposure of two selected 18-AA β-lactoglobulin-derived peptides loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) in a whey-protein induced CMA murine model.<h4>Methods</h4>The peptides were l"],"journal":["Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology"],"pubmed_title":["Inhibition of cow's milk allergy development in mice by oral delivery of β-lactoglobulin-derived peptides loaded PLGA nanoparticles is associated with systemic whey-specific immune silencing."],"pmcid":["PMC9291823"],"funding_grant_id":["201707720004"],"pubmed_authors":["Liu M","van Nostrum CF","Thijssen S","Hennink WE","Willemsen LEM","Garssen J"],"additional_accession":[]},"is_claimable":false,"name":"Inhibition of cow's milk allergy development in mice by oral delivery of β-lactoglobulin-derived peptides loaded PLGA nanoparticles is associated with systemic whey-specific immune silencing.","description":"<h4>Background</h4>Two to four percentage of infants are affected by cow's milk allergy (CMA), which persists in 20% of cases. Intervention approaches using early oral exposure to cow's milk protein or hydrolysed cow's milk formula are being studied for CMA prevention. Yet, concerns regarding safety and/or efficacy remain to be tackled in particular for high-risk non-exclusively breastfed infants. Therefore, safe and effective strategies to improve early life oral tolerance induction may be considered.<h4>Objective</h4>We aim to investigate the efficacy of CMA prevention using oral pre-exposure of two selected 18-AA β-lactoglobulin-derived peptides loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) in a whey-protein induced CMA murine model.<h4>Methods</h4>The peptides were l","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-05T11:50:38.613Z","creation":"2022-08-06T14:48:04.088Z"},"accession":"S-EPMC9291823","cross_references":{"pubmed":["34145667"],"doi":["10.1111/cea.13967"]}}