biostudies-literatureLiu MChina Scholarship CouncilNutricia Research B.V., Utrecht, the NetherlandsChina Scholarship Council (CSC)137-148https://www.ebi.ac.uk/biostudies/studies/S-EPMC9291823biostudies-literatureUnknown52(1)<h4>Background</h4>Two to four percentage of infants are affected by cow's milk allergy (CMA), which persists in 20% of cases. Intervention approaches using early oral exposure to cow's milk protein or hydrolysed cow's milk formula are being studied for CMA prevention. Yet, concerns regarding safety and/or efficacy remain to be tackled in particular for high-risk non-exclusively breastfed infants. Therefore, safe and effective strategies to improve early life oral tolerance induction may be considered.<h4>Objective</h4>We aim to investigate the efficacy of CMA prevention using oral pre-exposure of two selected 18-AA β-lactoglobulin-derived peptides loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) in a whey-protein induced CMA murine model.<h4>Methods</h4>The peptides were lClinical and experimental allergy : journal of the British Society for Allergy and Clinical ImmunologyInhibition of cow's milk allergy development in mice by oral delivery of β-lactoglobulin-derived peptides loaded PLGA nanoparticles is associated with systemic whey-specific immune silencing.PMC9291823201707720004Liu Mvan Nostrum CFThijssen SHennink WEWillemsen LEMGarssen JfalseInhibition of cow's milk allergy development in mice by oral delivery of β-lactoglobulin-derived peptides loaded PLGA nanoparticles is associated with systemic whey-specific immune silencing.<h4>Background</h4>Two to four percentage of infants are affected by cow's milk allergy (CMA), which persists in 20% of cases. Intervention approaches using early oral exposure to cow's milk protein or hydrolysed cow's milk formula are being studied for CMA prevention. Yet, concerns regarding safety and/or efficacy remain to be tackled in particular for high-risk non-exclusively breastfed infants. Therefore, safe and effective strategies to improve early life oral tolerance induction may be considered.<h4>Objective</h4>We aim to investigate the efficacy of CMA prevention using oral pre-exposure of two selected 18-AA β-lactoglobulin-derived peptides loaded poly (lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) in a whey-protein induced CMA murine model.<h4>Methods</h4>The peptides were l2022-01-01T00:00:00Z2022 Jan2025-04-05T11:50:38.613Z2022-08-06T14:48:04.088ZS-EPMC92918233414566710.1111/cea.13967