{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jarazo J"],"funding":["Deutsche Forschungsgemeinschaft","Horizon 2020 Framework Programme","Fonds National de la Recherche Luxembourg"],"pagination":["80-94"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9291890"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(1)"],"pubmed_abstract":["<h4>Background</h4>The etiology of Parkinson's disease (PD) is only partially understood despite the fact that environmental causes, risk factors, and specific gene mutations are contributors to the disease. Biallelic mutations in the phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) gene involved in mitochondrial homeostasis, vesicle trafficking, and autophagy are sufficient to cause PD.<h4>Objectives</h4>We sought to evaluate the difference between controls' and PINK1 patients' derived neurons in their transition from neuroepithelial stem cells to neurons, allowing us to identify potential pathways to target with repurposed compounds.<h4>Methods</h4>Using two-dimensional and three-dimensional models of patients' derived neurons we recapitulated PD-related phenotypes"],"journal":["Movement disorders : official journal of the Movement Disorder Society"],"pubmed_title":["Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment."],"pmcid":["PMC9291890"],"funding_grant_id":["INTER/JPND/14/02","FNR/P13/6682797","FOR2488","C13/BM/5791363","INTER/JPND/15/11092422","C17/BM/11676395","668738","AFR"],"pubmed_authors":["Modamio J","Antony PMA","Skwirblies F","Su J","Cruciani G","Rakovic A","Jarazo J","Arena G","Seibler P","Vitali A","Zaffaroni G","Schmidt R","Boussaad I","Griesbeck A","Gomez-Giro G","Qing X","Bolognin S","Sabate-Soler S","Monzel AS","Yuan L","Walter J","Rosety I","Schwamborn JC","Berger E","Brunelli F","Jager C","Barmpa K","Li W","Klein C","Saraiva C","Kruger R","Smits LM","Arias-Fuenzalida J","Schroder C"],"additional_accession":[]},"is_claimable":false,"name":"Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2-Hydroxypropyl-β-Cyclodextrin Treatment.","description":"<h4>Background</h4>The etiology of Parkinson's disease (PD) is only partially understood despite the fact that environmental causes, risk factors, and specific gene mutations are contributors to the disease. Biallelic mutations in the phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) gene involved in mitochondrial homeostasis, vesicle trafficking, and autophagy are sufficient to cause PD.<h4>Objectives</h4>We sought to evaluate the difference between controls' and PINK1 patients' derived neurons in their transition from neuroepithelial stem cells to neurons, allowing us to identify potential pathways to target with repurposed compounds.<h4>Methods</h4>Using two-dimensional and three-dimensional models of patients' derived neurons we recapitulated PD-related phenotypes","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-05-10T00:56:33.168Z","creation":"2024-11-07T08:39:55.179Z"},"accession":"S-EPMC9291890","cross_references":{"pubmed":["34637165"],"doi":["10.1002/mds.28810"]}}