{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Saito M"],"funding":["Genesis Oncology Trust","University of Otago"],"pagination":["1991-2002"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9294030"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["148(8)"],"pubmed_abstract":["<h4>Background</h4>Progression of cervical intraepithelial neoplasia (CIN) to higher grade disease is associated with persistent human papillomavirus (HPV) infection and an absence of immune-mediated regression. However, the immune microenvironment that distinguishes progression from persistent or regressing lesions has not been well defined.<h4>Methods</h4>A total of 69 patients under the age of 25 with high-risk HPV-positive cytology and biopsy-confirmed p16-positive CIN2 were included in the study. Biopsies were stained using 20 antibodies to a range of immune markers. Based on a 2-year follow-up, samples were analysed in \"progressor\" (CIN3 +) or \"persister/regressor\" (CIN1, 2 or normal) groups.<h4>Results</h4>Progression was most strongly associated with Blimp-1 positive cell staining "],"journal":["Journal of cancer research and clinical oncology"],"pubmed_title":["Blimp-1 is a prognostic indicator for progression of cervical intraepithelial neoplasia grade 2."],"pmcid":["PMC9294030"],"funding_grant_id":["2016"],"pubmed_authors":["Simcock B","Sykes P","Rajesh A","Innes C","Hibma M","Saito M","Fitzgerald P","van der Griend R"],"additional_accession":[]},"is_claimable":false,"name":"Blimp-1 is a prognostic indicator for progression of cervical intraepithelial neoplasia grade 2.","description":"<h4>Background</h4>Progression of cervical intraepithelial neoplasia (CIN) to higher grade disease is associated with persistent human papillomavirus (HPV) infection and an absence of immune-mediated regression. However, the immune microenvironment that distinguishes progression from persistent or regressing lesions has not been well defined.<h4>Methods</h4>A total of 69 patients under the age of 25 with high-risk HPV-positive cytology and biopsy-confirmed p16-positive CIN2 were included in the study. Biopsies were stained using 20 antibodies to a range of immune markers. Based on a 2-year follow-up, samples were analysed in \"progressor\" (CIN3 +) or \"persister/regressor\" (CIN1, 2 or normal) groups.<h4>Results</h4>Progression was most strongly associated with Blimp-1 positive cell staining ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2025-04-06T19:45:38.465Z","creation":"2025-04-06T19:45:38.465Z"},"accession":"S-EPMC9294030","cross_references":{"pubmed":["35386001"],"doi":["10.1007/s00432-022-03993-4"]}}