biostudies-literatureSaito MGenesis Oncology TrustUniversity of Otago1991-2002https://www.ebi.ac.uk/biostudies/studies/S-EPMC9294030biostudies-literatureUnknown148(8)<h4>Background</h4>Progression of cervical intraepithelial neoplasia (CIN) to higher grade disease is associated with persistent human papillomavirus (HPV) infection and an absence of immune-mediated regression. However, the immune microenvironment that distinguishes progression from persistent or regressing lesions has not been well defined.<h4>Methods</h4>A total of 69 patients under the age of 25 with high-risk HPV-positive cytology and biopsy-confirmed p16-positive CIN2 were included in the study. Biopsies were stained using 20 antibodies to a range of immune markers. Based on a 2-year follow-up, samples were analysed in "progressor" (CIN3 +) or "persister/regressor" (CIN1, 2 or normal) groups.<h4>Results</h4>Progression was most strongly associated with Blimp-1 positive cell staining Journal of cancer research and clinical oncologyBlimp-1 is a prognostic indicator for progression of cervical intraepithelial neoplasia grade 2.PMC92940302016Simcock BSykes PRajesh AInnes CHibma MSaito MFitzgerald Pvan der Griend RfalseBlimp-1 is a prognostic indicator for progression of cervical intraepithelial neoplasia grade 2.<h4>Background</h4>Progression of cervical intraepithelial neoplasia (CIN) to higher grade disease is associated with persistent human papillomavirus (HPV) infection and an absence of immune-mediated regression. However, the immune microenvironment that distinguishes progression from persistent or regressing lesions has not been well defined.<h4>Methods</h4>A total of 69 patients under the age of 25 with high-risk HPV-positive cytology and biopsy-confirmed p16-positive CIN2 were included in the study. Biopsies were stained using 20 antibodies to a range of immune markers. Based on a 2-year follow-up, samples were analysed in "progressor" (CIN3 +) or "persister/regressor" (CIN1, 2 or normal) groups.<h4>Results</h4>Progression was most strongly associated with Blimp-1 positive cell staining 2022-01-01T00:00:00Z2022 Aug2025-04-06T19:45:38.465Z2025-04-06T19:45:38.465ZS-EPMC92940303538600110.1007/s00432-022-03993-4