{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Machuka EM"],"funding":["Defense Threat Reduction Agency"],"pagination":["522"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9294756"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["<h4>Background</h4>African swine fever (ASF) is a lethal hemorrhagic disease affecting domestic pigs resulting in up to 100% mortality rates caused by the ASF virus (ASFV). The locally-adapted pigs in South-western Kenya have been reported to be resilient to disease and harsh climatic conditions and tolerate ASF; however, the mechanisms by which this tolerance is sustained remain largely unknown. We evaluated the gene expression patterns in spleen tissues of these locally-adapted pigs in response to varying infective doses of ASFV to elucidate the virus-host interaction dynamics.<h4>Methods</h4>Locally adapted pigs (n = 14) were experimentally infected with a high dose (1x10<sup>6</sup>HAD<sub>50</sub>), medium dose (1x10<sup>4</sup>HAD<sub>50</sub>), and low dose (1x10<sup>2</sup>HAD<sub>"],"journal":["BMC genomics"],"pubmed_title":["Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033)."],"pmcid":["PMC9294756"],"funding_grant_id":["HDTRA1-16-1-0050"],"pubmed_authors":["Pelle R","Juma J","Muigai AWT","Amimo JO","Abworo EO","Machuka EM"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome profile of spleen tissues from locally-adapted Kenyan pigs (Sus scrofa) experimentally infected with three varying doses of a highly virulent African swine fever virus genotype IX isolate: Ken12/busia.1 (ken-1033).","description":"<h4>Background</h4>African swine fever (ASF) is a lethal hemorrhagic disease affecting domestic pigs resulting in up to 100% mortality rates caused by the ASF virus (ASFV). The locally-adapted pigs in South-western Kenya have been reported to be resilient to disease and harsh climatic conditions and tolerate ASF; however, the mechanisms by which this tolerance is sustained remain largely unknown. We evaluated the gene expression patterns in spleen tissues of these locally-adapted pigs in response to varying infective doses of ASFV to elucidate the virus-host interaction dynamics.<h4>Methods</h4>Locally adapted pigs (n = 14) were experimentally infected with a high dose (1x10<sup>6</sup>HAD<sub>50</sub>), medium dose (1x10<sup>4</sup>HAD<sub>50</sub>), and low dose (1x10<sup>2</sup>HAD<sub>","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-05-27T20:31:01.212Z","creation":"2025-02-19T02:44:00.01Z"},"accession":"S-EPMC9294756","cross_references":{"pubmed":["35854219"],"doi":["10.1186/s12864-022-08754-8"]}}