{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang MH"],"funding":["Ministry of Science and Technology","Ministry of Education","Kaohsiung Medical University","CCH-KMU Research Project","Taiwan Protein Project","NSYSU-KMU Research Project"],"pagination":["551-564"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9296191"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(2)"],"pubmed_abstract":["Alzheimer's disease (AD) is the most common cause of dementia in late life. It is difficult to precisely diagnose AD at early stages, making biomarker search essential for further developments. The objective of this study was to identify protein biomarkers associated with aluminum ions toxicity (AD-like toxicity) in a human neuroblastoma cell model, SH-SY5Y and assess potential prevention by NAP (NAPVSIPQ). Complete proteomic techniques were implemented. Four proteins were identified as up-regulated with aluminum ion treatment, CBP80/20-dependent translation initiation factor (CTIF), Early endosome antigen 1 (EEA1), Leucine-rich repeat neuronal protein 4 (LRRN4) and Phosphatidylinositol 3-kinase regulatory subunit beta (PI3KR2). Of these four proteins, EEA1 and PI3KR2 were down-regulated a"],"journal":["Journal of food and drug analysis"],"pubmed_title":["Reduction of aluminum ion neurotoxicity through a small peptide application - NAP treatment of Alzheimer's disease."],"pmcid":["PMC9296191"],"funding_grant_id":["NSYSUKMU106-P011","105KMUOR05","KMU-O104003","KMU-TP105E12","105-CCH-KMU-005","AS-KPQ-105-TPP","MOST 107-2320-B-037-003"],"pubmed_authors":["Lee YC","Chen KC","Gozes I","Yang MH","Lin YF","Tyan YC","Lin PC","Chen SC","Wu HY","Huang MY"],"additional_accession":[]},"is_claimable":false,"name":"Reduction of aluminum ion neurotoxicity through a small peptide application - NAP treatment of Alzheimer's disease.","description":"Alzheimer's disease (AD) is the most common cause of dementia in late life. It is difficult to precisely diagnose AD at early stages, making biomarker search essential for further developments. The objective of this study was to identify protein biomarkers associated with aluminum ions toxicity (AD-like toxicity) in a human neuroblastoma cell model, SH-SY5Y and assess potential prevention by NAP (NAPVSIPQ). Complete proteomic techniques were implemented. Four proteins were identified as up-regulated with aluminum ion treatment, CBP80/20-dependent translation initiation factor (CTIF), Early endosome antigen 1 (EEA1), Leucine-rich repeat neuronal protein 4 (LRRN4) and Phosphatidylinositol 3-kinase regulatory subunit beta (PI3KR2). Of these four proteins, EEA1 and PI3KR2 were down-regulated a","dates":{"release":"2019-01-01T00:00:00Z","publication":"2019 Apr","modification":"2025-04-26T13:07:47.384Z","creation":"2025-02-19T04:37:39.532Z"},"accession":"S-EPMC9296191","cross_references":{"pubmed":["30987727"],"doi":["10.1016/j.jfda.2018.11.009"]}}