{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ye W"],"funding":["National Natural Science Foundation of China"],"pagination":["9225647"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9296324"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2022"],"pubmed_abstract":["Bacterial contamination and biofilm formation onpercutaneous implants can lead to device failure and be life-threatening. To solve this issue, we constructed a carboxymethyl dextran- (CMD-) based nanomicelle antibacterial coating on the microarc-oxidized titanium (MAO-Ti) surface (described in the supplementary file). The self-assembled CMD-based nanomicelles and octadecylamine (ODA) were developed as a drug carrier and loaded with minocycline (MC). The characterization and stability of the MC-loaded nanomicelles were determined. The surface roughness, hydrophilicity, and drug release property of the coatings were also investigated. Our findings showed that the cross-linked MC-loaded nanomicelles (MC@(ODA-CMD)<sub>CL</sub>) were more stable than the uncross-linked nanomicelles. Moreover, M"],"journal":["BioMed research international"],"pubmed_title":["Carboxymethyl Dextran-Based Nanomicelle Coatings on Microarc Oxidized Titanium Surface for Percutaneous Implants: Drug Release, Antibacterial Properties, and Biocompatibility."],"pmcid":["PMC9296324"],"funding_grant_id":["81901869"],"pubmed_authors":["Zhou M","Fan J","Ye W","Wei H","Zhang L","Yu J"],"additional_accession":[]},"is_claimable":false,"name":"Carboxymethyl Dextran-Based Nanomicelle Coatings on Microarc Oxidized Titanium Surface for Percutaneous Implants: Drug Release, Antibacterial Properties, and Biocompatibility.","description":"Bacterial contamination and biofilm formation onpercutaneous implants can lead to device failure and be life-threatening. To solve this issue, we constructed a carboxymethyl dextran- (CMD-) based nanomicelle antibacterial coating on the microarc-oxidized titanium (MAO-Ti) surface (described in the supplementary file). The self-assembled CMD-based nanomicelles and octadecylamine (ODA) were developed as a drug carrier and loaded with minocycline (MC). The characterization and stability of the MC-loaded nanomicelles were determined. The surface roughness, hydrophilicity, and drug release property of the coatings were also investigated. Our findings showed that the cross-linked MC-loaded nanomicelles (MC@(ODA-CMD)<sub>CL</sub>) were more stable than the uncross-linked nanomicelles. Moreover, M","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-07-14T16:43:39.292Z","creation":"2025-04-06T19:46:03.005Z"},"accession":"S-EPMC9296324","cross_references":{"pubmed":["35865662"],"doi":["10.1155/2022/9225647"]}}