biostudies-literatureUnknown127(2)Pang X<h4>Background</h4>The potential of using magnetic resonance image tumour-regression grading (MRI-TRG) system to predict pathological TRG is debatable for locally advanced rectal cancer treated by neoadjuvant radiochemotherapy.<h4>Methods</h4>Referring to the American Joint Committee on Cancer/College of American Pathologists (AJCC/CAP) TRG classification scheme, a new four-category MRI-TRG system based on the volumetric analysis of the residual tumour and radiochemotherapy induced anorectal fibrosis was established. The agreement between them was evaluated by Kendall's tau-b test, while Kaplan-Meier analysis was used to calculate survival outcomes.<h4>Results</h4>In total, 1033 patients were included. Good agreement between MRI-TRG and AJCC/CAP TRG classifications was observed (k = 0.671)British journal of cancer268-277https://www.ebi.ac.uk/biostudies/studies/S-EPMC9296509biostudies-literatureA new magnetic resonance imaging tumour response grading scheme for locally advanced rectal cancer.PMC9296509Zheng JYu LChen HWan XPang XXie PMeng XfalseA new magnetic resonance imaging tumour response grading scheme for locally advanced rectal cancer.<h4>Background</h4>The potential of using magnetic resonance image tumour-regression grading (MRI-TRG) system to predict pathological TRG is debatable for locally advanced rectal cancer treated by neoadjuvant radiochemotherapy.<h4>Methods</h4>Referring to the American Joint Committee on Cancer/College of American Pathologists (AJCC/CAP) TRG classification scheme, a new four-category MRI-TRG system based on the volumetric analysis of the residual tumour and radiochemotherapy induced anorectal fibrosis was established. The agreement between them was evaluated by Kendall's tau-b test, while Kaplan-Meier analysis was used to calculate survival outcomes.<h4>Results</h4>In total, 1033 patients were included. Good agreement between MRI-TRG and AJCC/CAP TRG classifications was observed (k = 0.671)2022-01-01T00:00:00Z2022 Jul2025-04-22T13:05:36.868Z2025-04-06T00:32:16.041ZS-EPMC92965093538814010.1038/s41416-022-01801-x