{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mashau RC"],"funding":["Medical Research Council","Sanofi Pasteur","National Institutes of Health","Bill and Melinda Gates Foundation"],"pagination":["e1170-e1178"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9296659"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(8)"],"pubmed_abstract":["<h4>Background</h4>Few population-level estimates of invasive neonatal infections have been reported from sub-Saharan Africa. We estimated the national incidence risk, aetiology, and pathogen antimicrobial susceptibility for culture-confirmed neonatal bloodstream infections and meningitis in South Africa.<h4>Methods</h4>We conducted a cross-sectional study of neonates (<28 days of life) admitted to neonatal or paediatric wards of 256 public sector health facilities in South Africa during 2014-19. Diagnostic pathology records from Jan 1, 2014, to Dec 31, 2019, were extracted from a national pathology data warehouse. A case was defined as a neonate with at least one positive blood or cerebrospinal fluid culture during a 14-day period. Incidence risk was calculated using annual numbers of reg"],"journal":["The Lancet. Global health"],"pubmed_title":["Culture-confirmed neonatal bloodstream infections and meningitis in South Africa, 2014-19: a cross-sectional study."],"pmcid":["PMC9296659"],"funding_grant_id":["MR/V033417/1","INV008112","K43 TW010682","1R01AI118511-01A1"],"pubmed_authors":["Magobo RE","Baby GERMS-SA","Meiring ST","Perovic O","Quan VC","Govender NP","Velaphi S","von Gottberg A","Mashau RC","Cohen C","Dramowski A","van Schalkwyk E"],"additional_accession":[]},"is_claimable":false,"name":"Culture-confirmed neonatal bloodstream infections and meningitis in South Africa, 2014-19: a cross-sectional study.","description":"<h4>Background</h4>Few population-level estimates of invasive neonatal infections have been reported from sub-Saharan Africa. We estimated the national incidence risk, aetiology, and pathogen antimicrobial susceptibility for culture-confirmed neonatal bloodstream infections and meningitis in South Africa.<h4>Methods</h4>We conducted a cross-sectional study of neonates (<28 days of life) admitted to neonatal or paediatric wards of 256 public sector health facilities in South Africa during 2014-19. Diagnostic pathology records from Jan 1, 2014, to Dec 31, 2019, were extracted from a national pathology data warehouse. A case was defined as a neonate with at least one positive blood or cerebrospinal fluid culture during a 14-day period. Incidence risk was calculated using annual numbers of reg","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Aug","modification":"2026-06-04T03:26:24.055Z","creation":"2022-08-08T22:17:54.279Z"},"accession":"S-EPMC9296659","cross_references":{"pubmed":["35839815"],"doi":["10.1016/S2214-109X(22)00246-7"]}}