{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boccaccio A"],"funding":["Compagnia di San Paolo"],"pagination":["2578-2592"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9299152"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["289(9)"],"pubmed_abstract":["Membrane asymmetry is important for cellular physiology and established by energy-dependent unidirectional lipid translocases, which have diverse physiological functions in plants. By contrast, the role of phospholipid scrambling (PLS), the passive bidirectional lipid transfer leading to the break-down of membrane asymmetry, is currently still unexplored. The Arabidopsis thaliana genome contains a single gene (At1g73020) with homology to the eukaryotic TMEM16 family of Ca<sup>2+</sup> -activated phospholipid scramblases. Here, we investigated the protein function of this Arabidopsis homolog. Fluorescent AtTMEM16 fusions localized to the ER both in transiently expressing Arabidopsis protoplasts and HEK293 cells. A putative scrambling domain (SCRD) was identified on the basis of sequence con"],"journal":["The FEBS journal"],"pubmed_title":["Phospholipid scrambling by a TMEM16 homolog of Arabidopsis thaliana."],"pmcid":["PMC9299152"],"funding_grant_id":["2013.0922"],"pubmed_authors":["Boccaccio A","Scholz-Starke J","Picco C","Di Zanni E"],"additional_accession":[]},"is_claimable":false,"name":"Phospholipid scrambling by a TMEM16 homolog of Arabidopsis thaliana.","description":"Membrane asymmetry is important for cellular physiology and established by energy-dependent unidirectional lipid translocases, which have diverse physiological functions in plants. By contrast, the role of phospholipid scrambling (PLS), the passive bidirectional lipid transfer leading to the break-down of membrane asymmetry, is currently still unexplored. The Arabidopsis thaliana genome contains a single gene (At1g73020) with homology to the eukaryotic TMEM16 family of Ca<sup>2+</sup> -activated phospholipid scramblases. Here, we investigated the protein function of this Arabidopsis homolog. Fluorescent AtTMEM16 fusions localized to the ER both in transiently expressing Arabidopsis protoplasts and HEK293 cells. A putative scrambling domain (SCRD) was identified on the basis of sequence con","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-04-08T10:20:45.663Z","creation":"2025-04-04T22:12:28.78Z"},"accession":"S-EPMC9299152","cross_references":{"pubmed":["34775680"],"doi":["10.1111/febs.16279"]}}