{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(29)"],"submitter":["Van Dyke ET"],"pubmed_abstract":["Zero- to ultralow-field nuclear magnetic resonance (ZULF NMR) is a rapidly developing form of spectroscopy that provides rich spectroscopic information in the absence of large magnetic fields. However, signal acquisition still requires a mechanism for generating a bulk magnetic moment for detection, and the currently used methods only apply to a limited pool of chemicals or come at prohibitively high cost. We demonstrate that the parahydrogen-based SABRE (signal amplification by reversible exchange)-Relay method can be used as a more general means of generating hyperpolarized analytes for ZULF NMR by observing zero-field <i>J</i>-spectra of [<sup>13</sup>C]-methanol, [1-<sup>13</sup>C]-ethanol, and [2-<sup>13</sup>C]-ethanol in both <sup>13</sup>C-isotopically enriched and natural abundance samples. We explore the magnetic field dependence of the SABRE-Relay efficiency and show the existence of a second maximum at 19.0 ± 0.3 mT. Despite presence of water, SABRE-Relay is used to hyperpolarize ethanol extracted from a store-bought sample of vodka (%<i>P</i><sub>H</sub> ~ 0.1%)."],"journal":["Science advances"],"pagination":["eabp9242"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9299534"],"repository":["biostudies-literature"],"pubmed_title":["Relayed hyperpolarization for zero-field nuclear magnetic resonance."],"pmcid":["PMC9299534"],"pubmed_authors":["Sheberstov KF","Hu Y","Picazo-Frutos R","Budker D","Eills J","Barskiy DA","Van Dyke ET"],"additional_accession":[]},"is_claimable":false,"name":"Relayed hyperpolarization for zero-field nuclear magnetic resonance.","description":"Zero- to ultralow-field nuclear magnetic resonance (ZULF NMR) is a rapidly developing form of spectroscopy that provides rich spectroscopic information in the absence of large magnetic fields. However, signal acquisition still requires a mechanism for generating a bulk magnetic moment for detection, and the currently used methods only apply to a limited pool of chemicals or come at prohibitively high cost. We demonstrate that the parahydrogen-based SABRE (signal amplification by reversible exchange)-Relay method can be used as a more general means of generating hyperpolarized analytes for ZULF NMR by observing zero-field <i>J</i>-spectra of [<sup>13</sup>C]-methanol, [1-<sup>13</sup>C]-ethanol, and [2-<sup>13</sup>C]-ethanol in both <sup>13</sup>C-isotopically enriched and natural abundance samples. We explore the magnetic field dependence of the SABRE-Relay efficiency and show the existence of a second maximum at 19.0 ± 0.3 mT. Despite presence of water, SABRE-Relay is used to hyperpolarize ethanol extracted from a store-bought sample of vodka (%<i>P</i><sub>H</sub> ~ 0.1%).","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-03-27T16:14:15.647Z","creation":"2025-02-19T02:26:45.857Z"},"accession":"S-EPMC9299534","cross_references":{"pubmed":["35857837"],"doi":["10.1126/sciadv.abp9242"]}}