biostudies-literatureAdler HMedical Research CouncilWellcome Trust1153-1162https://www.ebi.ac.uk/biostudies/studies/S-EPMC9300470biostudies-literatureUnknown22(8)<h4>Background</h4>Cases of human monkeypox are rarely seen outside of west and central Africa. There are few data regarding viral kinetics or the duration of viral shedding and no licensed treatments. Two oral drugs, brincidofovir and tecovirimat, have been approved for treatment of smallpox and have demonstrated efficacy against monkeypox in animals. Our aim was to describe the longitudinal clinical course of monkeypox in a high-income setting, coupled with viral dynamics, and any adverse events related to novel antiviral therapies.<h4>Methods</h4>In this retrospective observational study, we report the clinical features, longitudinal virological findings, and response to off-label antivirals in seven patients with monkeypox who were diagnosed in the UK between 2018 and 2021, identified The Lancet. Infectious diseasesClinical features and management of human monkeypox: a retrospective observational study in the UK.PMC9300470211153/Z/18/ZMR/V004832/1215091/Z/18/ZMC_PC_19059209075/Z/17/ZMR/V028618/1Botgros AFrost KKhoo SHPerkins SOliver CParsons JBlanchard TJBrown CSRampling TWilliams AJoyce JHine PTunbridge AJDewynter AHobson GTaylor CFletcher TEDouthwaite STWigglesworth NNeary ADixon JO'Hara GSmielewska ATaha YHruby DEMair LAbrahamsen JSchwab UBhagani SLyons ARatcliffe LNsutebu EStorey MZatyka EBeeching NJRyan HDavies Gvan Nipsen Tot Pannerden CHicks SRMayell SBrindley CHalfhide CSykes AAthan BOwens SWinslow HJacobs MDunning Jvan Aartsen JHopkins SNebbia GBeadsworth MBRodger ALuintel ASemple MGBeviz CMitchell HHoulihan CFPrice DAAarons EJSnell LBAl-Balushi AHoyle MCRiordan AWong WAllen DEmonts MGoodman AKabia MSmall JGould SCeesay YMcNicholas PCarpenter OWarren SFirth RPaul PSehmbey KBenson CIlozue COsborne JCCarlin FSasson MMepham SSridhar LParker SSen AWingfield TAlozie-Otuka EBrooks TEvans AFurneaux JPrice NMAdler HGillespie AMacMahon ESpence ODuncan CJLamb LSchmid MLTurtle LStevenson DTruelove EBall RLevitt DWoolley SMahungu TGnanalingham CTaj UDas UWard MJoekes EPorter RJTabios FWarrell CEWalker NFDryden MMarshall SCropley IJohnson CAbdul ASullivan TEyton-Chong CKAbouyannis MSmith CHunter ERGargee LBugert JJMcBride JNHS England High Consequence Infectious Diseases (Airborne) NetworkChawla AHart INixon SNewsholme WMukwaira EPayne BLarru BAston SPorter DGibney BfalseClinical features and management of human monkeypox: a retrospective observational study in the UK.<h4>Background</h4>Cases of human monkeypox are rarely seen outside of west and central Africa. There are few data regarding viral kinetics or the duration of viral shedding and no licensed treatments. Two oral drugs, brincidofovir and tecovirimat, have been approved for treatment of smallpox and have demonstrated efficacy against monkeypox in animals. Our aim was to describe the longitudinal clinical course of monkeypox in a high-income setting, coupled with viral dynamics, and any adverse events related to novel antiviral therapies.<h4>Methods</h4>In this retrospective observational study, we report the clinical features, longitudinal virological findings, and response to off-label antivirals in seven patients with monkeypox who were diagnosed in the UK between 2018 and 2021, identified 2022-01-01T00:00:00Z2022 Aug2025-04-27T03:00:24.227Z2025-02-19T00:27:15.584ZS-EPMC93004703562338010.1016/S1473-3099(22)00228-6