biostudies-literatureUnknown27(7)Li CNHLBI NIH HHS<h4>Significance</h4>Intravascular imaging is key to investigations into atherosclerotic plaque pathobiology and cardiovascular diagnostics overall. The development of multimodal imaging devices compatible with intracoronary applications has the potential to address limitations of currently available single-modality systems.<h4>Aim</h4>We designed and characterized a robust, high performance multimodal imaging system that combines optical coherence tomography (OCT) and multispectral fluorescence lifetime imaging (FLIm) for intraluminal simultaneous assessment of structural and biochemical properties of coronary arteries.<h4>Approach</h4>Several shortcomings of existing FLIm-OCT catheter systems are addressed by adopting key features, namely (1) a custom fiber optic rotary joint based on anJournal of biomedical opticshttps://www.ebi.ac.uk/biostudies/studies/S-EPMC9300477biostudies-literatureDual-modality fluorescence lifetime imaging-optical coherence tomography intravascular catheter system with freeform catheter optics.PMC9300477R01 HL157712Li CMarcu LBec JZhou XfalseDual-modality fluorescence lifetime imaging-optical coherence tomography intravascular catheter system with freeform catheter optics.<h4>Significance</h4>Intravascular imaging is key to investigations into atherosclerotic plaque pathobiology and cardiovascular diagnostics overall. The development of multimodal imaging devices compatible with intracoronary applications has the potential to address limitations of currently available single-modality systems.<h4>Aim</h4>We designed and characterized a robust, high performance multimodal imaging system that combines optical coherence tomography (OCT) and multispectral fluorescence lifetime imaging (FLIm) for intraluminal simultaneous assessment of structural and biochemical properties of coronary arteries.<h4>Approach</h4>Several shortcomings of existing FLIm-OCT catheter systems are addressed by adopting key features, namely (1) a custom fiber optic rotary joint based on an2022-01-01T00:00:00Z2022 Jul2025-04-25T18:08:39.978Z2025-02-19T01:34:36.612ZS-EPMC93004773586457410.1117/1.JBO.27.7.076005