biostudies-literatureUnknown10Yu CTwo new pyranone derivatives phomapyrone A (2) and phomapyrone B (3), one new coumarin 11<i>S,</i> 13<i>R</i>-(+)-phomacumarin A (1), three known pyranones (4-6), together with three known amide alkaloids fuscoatramides A-C (7-9), as well as 9<i>S,</i> 11<i>R</i>-(+)-ascosalitoxin (10) were isolated from the endophytic fungus <i>Phoma</i> sp. YN02-P-3, which was isolated from the healthy leaf tissue of a Paulownia tree in Yunnan Province, China. Their structures were elucidated using extensive NMR spectroscopic and HRESIMS data and by comparing the information with literature data. In addition, all compounds were tested for their cytotoxicity activity against human tumor cell lines, and the results showed that new compounds 1-3 showed moderate inhibitory activity against the HL-60 cell line with IC₅₀ values of 31.02, 34.62, and 27.90 <i>μ</i>M, respectively.Frontiers in chemistry950726https://www.ebi.ac.uk/biostudies/studies/S-EPMC9300907biostudies-literaturePyranone Derivatives With Antitumor Activities, From the Endophytic Fungus <i>Phoma</i> sp. YN02-P-3.PMC9300907Liang SSun MYu CChen HPei YWang HNian YfalsePyranone Derivatives With Antitumor Activities, From the Endophytic Fungus <i>Phoma</i> sp. YN02-P-3.Two new pyranone derivatives phomapyrone A (2) and phomapyrone B (3), one new coumarin 11<i>S,</i> 13<i>R</i>-(+)-phomacumarin A (1), three known pyranones (4-6), together with three known amide alkaloids fuscoatramides A-C (7-9), as well as 9<i>S,</i> 11<i>R</i>-(+)-ascosalitoxin (10) were isolated from the endophytic fungus <i>Phoma</i> sp. YN02-P-3, which was isolated from the healthy leaf tissue of a Paulownia tree in Yunnan Province, China. Their structures were elucidated using extensive NMR spectroscopic and HRESIMS data and by comparing the information with literature data. In addition, all compounds were tested for their cytotoxicity activity against human tumor cell lines, and the results showed that new compounds 1-3 showed moderate inhibitory activity against the HL-60 cell line with IC₅₀ values of 31.02, 34.62, and 27.90 <i>μ</i>M, respectively.2022-01-01T00:00:00Z20222025-04-26T23:18:23.234Z2025-04-06T17:34:50.562ZS-EPMC93009073587304110.3389/fchem.2022.950726