{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Huang J"],"pubmed_abstract":["<b>Objective:</b> To demonstrate the effectiveness of Huangqin decoction (Huangqin Tang in Chinese, HQT) combined with Radix <i>Actinidiae chinensis</i> (Tengligen in Chinese, TLG) under the guidance of \"dampness-heat theory\" in preventing and treating colorectal cancer (CRC) with dampness-heat accumulation and to preliminarily reveal its mechanism. <b>Methods</b>: The mice model of CRC was established by intraperitoneal injection of AOM combined with consumption of 2.5% DSS solution, and celecoxib, HQT, TLG, and their combination (HQT + TLG) were administered at the same time. The physical signs and death of the mice were observed daily. At the end of the experiment, the colorectal tissue was dissected, and the tumor was observed and counted. HE staining and Masson's staining were used to"],"journal":["Frontiers in pharmacology"],"pagination":["933070"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9301036"],"repository":["biostudies-literature"],"pubmed_title":["Synergistic Effect of Huangqin Decoction Combined Treatment With Radix <i>Actinidiae chinensis</i> on DSS and AOM-Induced Colorectal Cancer."],"pmcid":["PMC9301036"],"pubmed_authors":["Zhang G","Wu M","Huang J","Jiang T","Kang J","Xu X","Zhao Z","Yang C","Xu J","Dengzhang Y","Lou Z"],"additional_accession":[]},"is_claimable":false,"name":"Synergistic Effect of Huangqin Decoction Combined Treatment With Radix <i>Actinidiae chinensis</i> on DSS and AOM-Induced Colorectal Cancer.","description":"<b>Objective:</b> To demonstrate the effectiveness of Huangqin decoction (Huangqin Tang in Chinese, HQT) combined with Radix <i>Actinidiae chinensis</i> (Tengligen in Chinese, TLG) under the guidance of \"dampness-heat theory\" in preventing and treating colorectal cancer (CRC) with dampness-heat accumulation and to preliminarily reveal its mechanism. <b>Methods</b>: The mice model of CRC was established by intraperitoneal injection of AOM combined with consumption of 2.5% DSS solution, and celecoxib, HQT, TLG, and their combination (HQT + TLG) were administered at the same time. The physical signs and death of the mice were observed daily. At the end of the experiment, the colorectal tissue was dissected, and the tumor was observed and counted. HE staining and Masson's staining were used to","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T15:16:52.556Z","creation":"2025-04-07T01:53:28.149Z"},"accession":"S-EPMC9301036","cross_references":{"pubmed":["35873550"],"doi":["10.3389/fphar.2022.933070"]}}