{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Fang C"],"funding":["Natural Science Foundation of Hunan Province","National Natural Science Foundation of China"],"pubmed_abstract":["<b>Background:</b> Dexmedetomidine is a commonly used clinical sedative; however, the drug response varies among individuals. Thus, the purpose of this study was to explore the association between dexmedetomidine response and gene polymorphisms related to drug-metabolizing enzymes and drug response (<i>CYP2A6</i>, <i>UGT2B10</i>, <i>UGT1A4</i>, <i>ADRA2A</i>, <i>ADRA2B</i>, <i>ADRA2C</i>, <i>GABRA1</i>, <i>GABRB2</i>, and <i>GLRA1</i>). <b>Methods:</b> This study was a prospective cohort study. A total of 194 female patients aged 18-60 years, American Society of Anesthesiologists (ASA) score I-II, who underwent laparoscopy at the Third Xiangya Hospital of Central South University, were included. The sedative effect was assessed every 2 min using the Ramsay score, and the patient's heart ra"],"journal":["Frontiers in pharmacology"],"pagination":["943200"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9301121"],"repository":["biostudies-literature"],"pubmed_title":["CYP2A6 and GABRA2 Gene Polymorphisms are Associated With Dexmedetomidine Drug Response."],"pmcid":["PMC9301121"],"pubmed_authors":["Xia Y","Pei Q","Ouyang W","Chen M","Fang C","Zeng Y","Luo S"],"additional_accession":[]},"is_claimable":false,"name":"CYP2A6 and GABRA2 Gene Polymorphisms are Associated With Dexmedetomidine Drug Response.","description":"<b>Background:</b> Dexmedetomidine is a commonly used clinical sedative; however, the drug response varies among individuals. Thus, the purpose of this study was to explore the association between dexmedetomidine response and gene polymorphisms related to drug-metabolizing enzymes and drug response (<i>CYP2A6</i>, <i>UGT2B10</i>, <i>UGT1A4</i>, <i>ADRA2A</i>, <i>ADRA2B</i>, <i>ADRA2C</i>, <i>GABRA1</i>, <i>GABRB2</i>, and <i>GLRA1</i>). <b>Methods:</b> This study was a prospective cohort study. A total of 194 female patients aged 18-60 years, American Society of Anesthesiologists (ASA) score I-II, who underwent laparoscopy at the Third Xiangya Hospital of Central South University, were included. The sedative effect was assessed every 2 min using the Ramsay score, and the patient's heart ra","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-09T14:24:28.134Z","creation":"2025-04-06T19:33:59.213Z"},"accession":"S-EPMC9301121","cross_references":{"pubmed":["35873555"],"doi":["10.3389/fphar.2022.943200"]}}