biostudies-literatureUnknown13Fang CNatural Science Foundation of Hunan ProvinceNational Natural Science Foundation of China<b>Background:</b> Dexmedetomidine is a commonly used clinical sedative; however, the drug response varies among individuals. Thus, the purpose of this study was to explore the association between dexmedetomidine response and gene polymorphisms related to drug-metabolizing enzymes and drug response (<i>CYP2A6</i>, <i>UGT2B10</i>, <i>UGT1A4</i>, <i>ADRA2A</i>, <i>ADRA2B</i>, <i>ADRA2C</i>, <i>GABRA1</i>, <i>GABRB2</i>, and <i>GLRA1</i>). <b>Methods:</b> This study was a prospective cohort study. A total of 194 female patients aged 18-60 years, American Society of Anesthesiologists (ASA) score I-II, who underwent laparoscopy at the Third Xiangya Hospital of Central South University, were included. The sedative effect was assessed every 2 min using the Ramsay score, and the patient's heart raFrontiers in pharmacology943200https://www.ebi.ac.uk/biostudies/studies/S-EPMC9301121biostudies-literatureCYP2A6 and GABRA2 Gene Polymorphisms are Associated With Dexmedetomidine Drug Response.PMC9301121Xia YPei QOuyang WChen MFang CZeng YLuo SfalseCYP2A6 and GABRA2 Gene Polymorphisms are Associated With Dexmedetomidine Drug Response.<b>Background:</b> Dexmedetomidine is a commonly used clinical sedative; however, the drug response varies among individuals. Thus, the purpose of this study was to explore the association between dexmedetomidine response and gene polymorphisms related to drug-metabolizing enzymes and drug response (<i>CYP2A6</i>, <i>UGT2B10</i>, <i>UGT1A4</i>, <i>ADRA2A</i>, <i>ADRA2B</i>, <i>ADRA2C</i>, <i>GABRA1</i>, <i>GABRB2</i>, and <i>GLRA1</i>). <b>Methods:</b> This study was a prospective cohort study. A total of 194 female patients aged 18-60 years, American Society of Anesthesiologists (ASA) score I-II, who underwent laparoscopy at the Third Xiangya Hospital of Central South University, were included. The sedative effect was assessed every 2 min using the Ramsay score, and the patient's heart ra2022-01-01T00:00:00Z20222026-05-09T14:24:28.134Z2025-04-06T19:33:59.213ZS-EPMC93011213587355510.3389/fphar.2022.943200