{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Su J"],"pubmed_abstract":["Three chalcone derivatives, abelmanihotols A-C <b>(1-3)</b>, and nine known compounds were isolated from <i>A. manihot</i> seeds, and their structures were determined using HRESIMS and NMR spectroscopic analysis. Compound <b>1</b> exhibited the most potent inhibitory effect (IC<sub>50</sub> = 4.79 ± 0.72 μM) against lipopolysaccharide (LPS)-induced NO release in THP-1 cells, and <b>s</b>ignificantly inhibited interleukin 1β (IL-1β) secretion, which is stimulated by LPS plus nigericin (IC<sub>50</sub> = 11.86 ± 1.20 μM), ATP or MSU, in THP-1 cells. A preliminary mechanism of action study indicated that compound <b>1</b> blocked the formation of nucleotide oligomerization domain-like receptor protein-3 (NLRP3) inflammasome formation by suppressing apoptosis-associated speck-like protein olig"],"journal":["Frontiers in pharmacology"],"pagination":["932198"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9301202"],"repository":["biostudies-literature"],"pubmed_title":["Chalcone Derivatives From <i>Abelmoschus manihot</i> Seeds Restrain NLRP3 Inflammasome Assembly by Inhibiting ASC Oligomerization."],"pmcid":["PMC9301202"],"pubmed_authors":["Kang X","Liu J","Tao Y","Zhang Y","Diao Q","Su J","Liu D","Yang F","Meng X"],"additional_accession":[]},"is_claimable":false,"name":"Chalcone Derivatives From <i>Abelmoschus manihot</i> Seeds Restrain NLRP3 Inflammasome Assembly by Inhibiting ASC Oligomerization.","description":"Three chalcone derivatives, abelmanihotols A-C <b>(1-3)</b>, and nine known compounds were isolated from <i>A. manihot</i> seeds, and their structures were determined using HRESIMS and NMR spectroscopic analysis. Compound <b>1</b> exhibited the most potent inhibitory effect (IC<sub>50</sub> = 4.79 ± 0.72 μM) against lipopolysaccharide (LPS)-induced NO release in THP-1 cells, and <b>s</b>ignificantly inhibited interleukin 1β (IL-1β) secretion, which is stimulated by LPS plus nigericin (IC<sub>50</sub> = 11.86 ± 1.20 μM), ATP or MSU, in THP-1 cells. A preliminary mechanism of action study indicated that compound <b>1</b> blocked the formation of nucleotide oligomerization domain-like receptor protein-3 (NLRP3) inflammasome formation by suppressing apoptosis-associated speck-like protein olig","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T11:51:24.882Z","creation":"2025-04-05T11:51:24.882Z"},"accession":"S-EPMC9301202","cross_references":{"pubmed":["35873581"],"doi":["10.3389/fphar.2022.932198"]}}