biostudies-literatureUnknown9Ramos-Rincon JM<h4>Background</h4>Autopsies can shed light on the pathogenesis of new and emerging diseases.<h4>Aim</h4>To describe needle core necropsy findings of the lung, heart, and liver in decedents with COVID-19.<h4>Material</h4>Cross-sectional study of needle core necropsies in patients who died with virologically confirmed COVID-19. Histopathological analyses were performed, and clinical data and patient course evaluated.<h4>Results</h4>Chest core necropsies were performed in 71 decedents with a median age of 81 years (range 52-97); 47 (65.3%) were men. The median interval from symptoms onset to death was 17.5 days (range 1-84). Samples of lung (<i>n</i> = 62, 87.3%), heart (<i>n</i> = 48, 67.6%) and liver (<i>n</i> = 39, 54.9%) were obtained. Fifty-one lung samples (82.3%) were abnormal: 19 (30Frontiers in medicine874307https://www.ebi.ac.uk/biostudies/studies/S-EPMC9301383biostudies-literaturePathological Findings Associated With SARS-CoV-2 on Postmortem Core Biopsies: Correlation With Clinical Presentation and Disease Course.PMC9301383Herrera-Garcia CMerino EEscribano IMoreno-Perez OFornes-Riera FEConcepcion-Aramendia LAranda IGarcia-Sevila RRamos-Rincon JMSanchez-Martinez ROrts-Llinares PAlenda CArenas-Jimenez JScholz AMunoz-Miguelsanz CAmo-Lozano APortilla-Tamarit JPedrero-Castillo VRibes-Mengual IJaime-Sanchez FAMarti-Pastor ASilva-Ortega SfalsePathological Findings Associated With SARS-CoV-2 on Postmortem Core Biopsies: Correlation With Clinical Presentation and Disease Course.<h4>Background</h4>Autopsies can shed light on the pathogenesis of new and emerging diseases.<h4>Aim</h4>To describe needle core necropsy findings of the lung, heart, and liver in decedents with COVID-19.<h4>Material</h4>Cross-sectional study of needle core necropsies in patients who died with virologically confirmed COVID-19. Histopathological analyses were performed, and clinical data and patient course evaluated.<h4>Results</h4>Chest core necropsies were performed in 71 decedents with a median age of 81 years (range 52-97); 47 (65.3%) were men. The median interval from symptoms onset to death was 17.5 days (range 1-84). Samples of lung (<i>n</i> = 62, 87.3%), heart (<i>n</i> = 48, 67.6%) and liver (<i>n</i> = 39, 54.9%) were obtained. Fifty-one lung samples (82.3%) were abnormal: 19 (302022-01-01T00:00:00Z20222025-04-25T18:09:37.153Z2025-04-06T07:30:56.653ZS-EPMC93013833587277810.3389/fmed.2022.874307