{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kawai T"],"funding":["NIDDK NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute","NINDS NIH HHS","NIDDK"],"pagination":["4161-4187"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9301870"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["78(9)"],"pubmed_abstract":["A disintegrin and metalloproteases (ADAMs) are key mediators of cell signaling by ectodomain shedding of various growth factors, cytokines, receptors and adhesion molecules at the cellular membrane. ADAMs regulate cell proliferation, cell growth, inflammation, and other regular cellular processes. ADAM17, the most extensively studied ADAM family member, is also known as tumor necrosis factor (TNF)-α converting enzyme (TACE). ADAMs-mediated shedding of cytokines such as TNF-α orchestrates immune system or inflammatory cascades and ADAMs-mediated shedding of growth factors causes cell growth or proliferation by transactivation of the growth factor receptors including epidermal growth factor receptor. Therefore, increased ADAMs-mediated shedding can induce inflammation, tissue remodeling and "],"journal":["Cellular and molecular life sciences : CMLS"],"pubmed_title":["Contribution of ADAM17 and related ADAMs in cardiovascular diseases."],"pmcid":["PMC9301870"],"funding_grant_id":["R01 HL133248","R01 HL128324","HL128324","R01 NS109382","DK111042","R01 DK111042"],"pubmed_authors":["Scalia R","Kawai T","Eguchi S","Elliott KJ"],"additional_accession":[]},"is_claimable":false,"name":"Contribution of ADAM17 and related ADAMs in cardiovascular diseases.","description":"A disintegrin and metalloproteases (ADAMs) are key mediators of cell signaling by ectodomain shedding of various growth factors, cytokines, receptors and adhesion molecules at the cellular membrane. ADAMs regulate cell proliferation, cell growth, inflammation, and other regular cellular processes. ADAM17, the most extensively studied ADAM family member, is also known as tumor necrosis factor (TNF)-α converting enzyme (TACE). ADAMs-mediated shedding of cytokines such as TNF-α orchestrates immune system or inflammatory cascades and ADAMs-mediated shedding of growth factors causes cell growth or proliferation by transactivation of the growth factor receptors including epidermal growth factor receptor. Therefore, increased ADAMs-mediated shedding can induce inflammation, tissue remodeling and ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-06-01T02:05:20.941Z","creation":"2025-06-01T02:05:20.941Z"},"accession":"S-EPMC9301870","cross_references":{"pubmed":["33575814"],"doi":["10.1007/s00018-021-03779-w"]}}