{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pesenti T"],"funding":["China Scholarship Council","European Research Council","Royal Society"],"pagination":["889-894"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9301905"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(7)"],"pubmed_abstract":["Macromolecular cryoprotectants based on polyampholytes are showing promise as supplemental cryoprotectants alongside conventional DMSO-based freezing. Here we exploit radical ring-opening (ter)polymerization to access ester-containing cryoprotective polyampholytes, which were shown to be degradable. Using a challenging cell monolayer cryopreservation model, the degradable polyampholytes were found to enhance post-thaw recovery when supplemented into DMSO. This demonstrates that degradable macromolecular cryoprotectants can be developed for application in biotechnology and biomedicine."],"journal":["ACS macro letters"],"pubmed_title":["Degradable Polyampholytes from Radical Ring-Opening Copolymerization Enhance Cellular Cryopreservation."],"pmcid":["PMC9301905"],"funding_grant_id":["866056","191037"],"pubmed_authors":["Pesenti T","Nicolas J","Tomas RMF","Gonzalez-Martinez N","Gibson MI","Zhu C"],"additional_accession":[]},"is_claimable":false,"name":"Degradable Polyampholytes from Radical Ring-Opening Copolymerization Enhance Cellular Cryopreservation.","description":"Macromolecular cryoprotectants based on polyampholytes are showing promise as supplemental cryoprotectants alongside conventional DMSO-based freezing. Here we exploit radical ring-opening (ter)polymerization to access ester-containing cryoprotective polyampholytes, which were shown to be degradable. Using a challenging cell monolayer cryopreservation model, the degradable polyampholytes were found to enhance post-thaw recovery when supplemented into DMSO. This demonstrates that degradable macromolecular cryoprotectants can be developed for application in biotechnology and biomedicine.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-04T18:37:15.152Z","creation":"2025-02-19T03:52:42.96Z"},"accession":"S-EPMC9301905","cross_references":{"pubmed":["35766585"],"doi":["10.1021/acsmacrolett.2c00298"]}}