biostudies-literatureCrow AJDChildren's Hospital of PhiladelphiaNIMH NIH HHSNational Institute of Mental Health2277-2292https://www.ebi.ac.uk/biostudies/studies/S-EPMC9302478biostudies-literatureUnknown188(8)Neurofibromatosis Type 1 (NF1) is a common genetic disorder frequently associated with cognitive deficits. Despite cognitive deficits being a key feature of NF1, the profile of such impairments in NF1 has been shown to be heterogeneous. Thus, we sought to quantitatively synthesize the extant literature on cognitive functioning in NF1. A random-effects meta-analysis of cross-sectional studies was carried out comparing cognitive functioning of patients with NF1 to typically developing or unaffected sibling comparison subjects of all ages. Analyses included 50 articles (Total N<sub>NF1</sub> = 1,522; M<sub>Age</sub> = 15.70 years, range = 0.52-69.60), yielding 460 effect sizes. Overall moderate deficits were observed [g = -0.64, 95% CI = (-0.69, -0.60)] wherein impairments differed at the levAmerican journal of medical genetics. Part AA systematic review and meta-analysis of intellectual, neuropsychological, and psychoeducational functioning in neurofibromatosis type 1.PMC9302478R01 MH120174MH119185R01 MH119185Moffit AJanssen JMMarshall CCrow AJDKohler CGMoberg PJRoalf DRBrennan LfalseA systematic review and meta-analysis of intellectual, neuropsychological, and psychoeducational functioning in neurofibromatosis type 1.Neurofibromatosis Type 1 (NF1) is a common genetic disorder frequently associated with cognitive deficits. Despite cognitive deficits being a key feature of NF1, the profile of such impairments in NF1 has been shown to be heterogeneous. Thus, we sought to quantitatively synthesize the extant literature on cognitive functioning in NF1. A random-effects meta-analysis of cross-sectional studies was carried out comparing cognitive functioning of patients with NF1 to typically developing or unaffected sibling comparison subjects of all ages. Analyses included 50 articles (Total N<sub>NF1</sub> = 1,522; M<sub>Age</sub> = 15.70 years, range = 0.52-69.60), yielding 460 effect sizes. Overall moderate deficits were observed [g = -0.64, 95% CI = (-0.69, -0.60)] wherein impairments differed at the lev2022-01-01T00:00:00Z2022 Aug2025-04-04T20:07:10.585Z2025-04-04T20:07:10.585ZS-EPMC93024783554630610.1002/ajmg.a.62773