biostudies-literatureUnknown12Zhang H<h4>Background</h4>Opioids are widely used during primary debulking surgery (PDS) for ovarian cancers, and a high mu-opioid receptor (MOR) expression predicts worse cancer outcomes. However, the impact of MOR expression on survival outcomes in ovarian cancers is still not clear.<h4>Methods</h4>A retrospective cohort study was conducted in patients who underwent PDS in ovarian cancer patients. MOR expression was measured in tumor and normal tissue. Primary outcomes were overall survival (OS) and disease-free survival (DFS). Secondary outcomes included perineural invasion (PNI), intraoperative sufentanil consumption, length of stay (LOS), and verbal numerical rating scale (VNRS) on postoperative day 1 (POD1), POD3, and POD5.<h4>Results</h4>After propensity score matching, a total of 366 patiFrontiers in oncology927262https://www.ebi.ac.uk/biostudies/studies/S-EPMC9302566biostudies-literatureAssociation of Mu-Opioid Receptor Expression With Long-Term Survival and Perineural Nerve Invasion in Patients Undergoing Surgery for Ovarian Cancer.PMC9302566Sun MGuo KLi TZhang HQu MSun CZhang XMiao CChen WWang YXu WSun ZfalseAssociation of Mu-Opioid Receptor Expression With Long-Term Survival and Perineural Nerve Invasion in Patients Undergoing Surgery for Ovarian Cancer.<h4>Background</h4>Opioids are widely used during primary debulking surgery (PDS) for ovarian cancers, and a high mu-opioid receptor (MOR) expression predicts worse cancer outcomes. However, the impact of MOR expression on survival outcomes in ovarian cancers is still not clear.<h4>Methods</h4>A retrospective cohort study was conducted in patients who underwent PDS in ovarian cancer patients. MOR expression was measured in tumor and normal tissue. Primary outcomes were overall survival (OS) and disease-free survival (DFS). Secondary outcomes included perineural invasion (PNI), intraoperative sufentanil consumption, length of stay (LOS), and verbal numerical rating scale (VNRS) on postoperative day 1 (POD1), POD3, and POD5.<h4>Results</h4>After propensity score matching, a total of 366 pati2022-01-01T00:00:00Z20222025-04-21T23:07:06.838Z2022-08-07T23:46:57.586ZS-EPMC93025663587514910.3389/fonc.2022.927262