biostudies-literatureNash DNational Institute of Allergy and Infectious DiseasesCity University of New YorkEunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNICHD NIH HHSNIAID NIH HHSe0271786https://www.ebi.ac.uk/biostudies/studies/S-EPMC9302833biostudies-literatureUnknown17(7)<h4>Objective</h4>To investigate the role of children in the home and household crowding as risk factors for severe COVID-19 disease.<h4>Methods</h4>We used interview data from 6,831 U.S. adults screened for the Communities, Households and SARS/CoV-2 Epidemiology (CHASING) COVID Cohort Study in April 2020.<h4>Results</h4>In logistic regression models, the adjusted odds ratio [aOR] of hospitalization due to COVID-19 for having (versus not having) children in the home was 10.5 (95% CI:5.7-19.1) among study participants living in multi-unit dwellings and 2.2 (95% CI:1.2-6.5) among those living in single unit dwellings. Among participants living in multi-unit dwellings, the aOR for COVID-19 hospitalization among participants with more than 4 persons in their household (versus 1 person) was 2.5 (95% CI:1.0-6.1), and 0.8 (95% CI:0.15-4.1) among those living in single unit dwellings.<h4>Conclusion</h4>Early in the US SARS-CoV-2 pandemic, certain household exposures likely increased the risk of both SARS-CoV-2 acquisition and the risk of severe COVID-19 disease.PloS oneHousehold factors and the risk of severe COVID-like illness early in the U.S. pandemic.PMC9302833P2C HD050924COVID-19 Grant Program of the CUNY Graduate School of Public Health and Health PolicyInstitute for Implementation Science in Population Health3UH3AI133675-04S1UH3 AI133675Rane MZimba RParcesepe AMirzayi CBerry AQasmieh SWaldron LNash DYou WKulkarni SGWestmoreland DMaroko ARCHASING COVID Cohort Study TeamKochhar SGrov CRobertson MfalseHousehold factors and the risk of severe COVID-like illness early in the U.S. pandemic.<h4>Objective</h4>To investigate the role of children in the home and household crowding as risk factors for severe COVID-19 disease.<h4>Methods</h4>We used interview data from 6,831 U.S. adults screened for the Communities, Households and SARS/CoV-2 Epidemiology (CHASING) COVID Cohort Study in April 2020.<h4>Results</h4>In logistic regression models, the adjusted odds ratio [aOR] of hospitalization due to COVID-19 for having (versus not having) children in the home was 10.5 (95% CI:5.7-19.1) among study participants living in multi-unit dwellings and 2.2 (95% CI:1.2-6.5) among those living in single unit dwellings. Among participants living in multi-unit dwellings, the aOR for COVID-19 hospitalization among participants with more than 4 persons in their household (versus 1 person) was 2.5 (95% CI:1.0-6.1), and 0.8 (95% CI:0.15-4.1) among those living in single unit dwellings.<h4>Conclusion</h4>Early in the US SARS-CoV-2 pandemic, certain household exposures likely increased the risk of both SARS-CoV-2 acquisition and the risk of severe COVID-19 disease.2022-01-01T00:00:00Z20222026-06-05T05:56:42.682Z2022-08-08T09:56:28.237ZS-EPMC93028333586241810.1371/journal.pone.0271786