{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["He J"],"pubmed_abstract":["<h4>Background</h4>Previous studies have shown that various cell indices are associated with a higher risk of venous thromboembolism (VTE), however, whether these findings reflect a causal relationship remains unclear. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to assess the causal association of various blood cells with VTE risk.<h4>Study design and methods</h4>Summary statistics of genetic instruments representing cell indices for erythrocytes, leukocytes, and platelets were extracted from genome-wide association studies of European ancestry, by Two-Sample Mendelian Randomization. Inverse variance weighting (IVW) was used as the primary analytical method for MR. Sensitivity analyses were performed to detect horizontal pleiotropy and heterogeneity.<h4>Results</h4>Genetically predicted red blood cell distribution width, mean reticulocyte volume, and mean red blood cell volume were positively associated with VTE, with odds ratio (OR) of 1.002 [CI 1.000-1.003, <i>P</i> = 0.022), 1.003 (CI 1.001-1.004, <i>P</i> = 0.001, respectively)] and 1.001 (CI 1.000-1.002, <i>P</i> = 0.005). Genetically predicted monocyte count was negatively correlated with VTE, with OR = 0.998 (CI 0.996-0.999, <i>P</i> = 0.041).<h4>Conclusion</h4>Genetically liability to high- red blood cell distribution width, mean reticulocyte volume, mean red blood cell volume, and low monocyte count are associated with the higher risk of VTE. Targeting these factors might be a potential strategy to prevent VTE."],"journal":["Frontiers in cardiovascular medicine"],"pagination":["919640"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9304581"],"repository":["biostudies-literature"],"pubmed_title":["Blood Cells and Venous Thromboembolism Risk: A Two-Sample Mendelian Randomization Study."],"pmcid":["PMC9304581"],"pubmed_authors":["Yang J","Ma R","Yao Y","Li J","He J","Jiang Q","Zhang N","Liu C","Shen Y"],"additional_accession":[]},"is_claimable":false,"name":"Blood Cells and Venous Thromboembolism Risk: A Two-Sample Mendelian Randomization Study.","description":"<h4>Background</h4>Previous studies have shown that various cell indices are associated with a higher risk of venous thromboembolism (VTE), however, whether these findings reflect a causal relationship remains unclear. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to assess the causal association of various blood cells with VTE risk.<h4>Study design and methods</h4>Summary statistics of genetic instruments representing cell indices for erythrocytes, leukocytes, and platelets were extracted from genome-wide association studies of European ancestry, by Two-Sample Mendelian Randomization. Inverse variance weighting (IVW) was used as the primary analytical method for MR. Sensitivity analyses were performed to detect horizontal pleiotropy and heterogeneity.<h4>Results</h4>Genetically predicted red blood cell distribution width, mean reticulocyte volume, and mean red blood cell volume were positively associated with VTE, with odds ratio (OR) of 1.002 [CI 1.000-1.003, <i>P</i> = 0.022), 1.003 (CI 1.001-1.004, <i>P</i> = 0.001, respectively)] and 1.001 (CI 1.000-1.002, <i>P</i> = 0.005). Genetically predicted monocyte count was negatively correlated with VTE, with OR = 0.998 (CI 0.996-0.999, <i>P</i> = 0.041).<h4>Conclusion</h4>Genetically liability to high- red blood cell distribution width, mean reticulocyte volume, mean red blood cell volume, and low monocyte count are associated with the higher risk of VTE. Targeting these factors might be a potential strategy to prevent VTE.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T07:33:26.985Z","creation":"2025-04-06T12:19:03.575Z"},"accession":"S-EPMC9304581","cross_references":{"pubmed":["35872889"],"doi":["10.3389/fcvm.2022.919640"]}}