biostudies-literatureUnknown9He J<h4>Background</h4>Previous studies have shown that various cell indices are associated with a higher risk of venous thromboembolism (VTE), however, whether these findings reflect a causal relationship remains unclear. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to assess the causal association of various blood cells with VTE risk.<h4>Study design and methods</h4>Summary statistics of genetic instruments representing cell indices for erythrocytes, leukocytes, and platelets were extracted from genome-wide association studies of European ancestry, by Two-Sample Mendelian Randomization. Inverse variance weighting (IVW) was used as the primary analytical method for MR. Sensitivity analyses were performed to detect horizontal pleiotropy and heterogeneity.<h4>Results</h4>Genetically predicted red blood cell distribution width, mean reticulocyte volume, and mean red blood cell volume were positively associated with VTE, with odds ratio (OR) of 1.002 [CI 1.000-1.003, <i>P</i> = 0.022), 1.003 (CI 1.001-1.004, <i>P</i> = 0.001, respectively)] and 1.001 (CI 1.000-1.002, <i>P</i> = 0.005). Genetically predicted monocyte count was negatively correlated with VTE, with OR = 0.998 (CI 0.996-0.999, <i>P</i> = 0.041).<h4>Conclusion</h4>Genetically liability to high- red blood cell distribution width, mean reticulocyte volume, mean red blood cell volume, and low monocyte count are associated with the higher risk of VTE. Targeting these factors might be a potential strategy to prevent VTE.Frontiers in cardiovascular medicine919640https://www.ebi.ac.uk/biostudies/studies/S-EPMC9304581biostudies-literatureBlood Cells and Venous Thromboembolism Risk: A Two-Sample Mendelian Randomization Study.PMC9304581Yang JMa RYao YLi JHe JJiang QZhang NLiu CShen YfalseBlood Cells and Venous Thromboembolism Risk: A Two-Sample Mendelian Randomization Study.<h4>Background</h4>Previous studies have shown that various cell indices are associated with a higher risk of venous thromboembolism (VTE), however, whether these findings reflect a causal relationship remains unclear. Therefore, we performed a two-sample Mendelian randomization (MR) analysis to assess the causal association of various blood cells with VTE risk.<h4>Study design and methods</h4>Summary statistics of genetic instruments representing cell indices for erythrocytes, leukocytes, and platelets were extracted from genome-wide association studies of European ancestry, by Two-Sample Mendelian Randomization. Inverse variance weighting (IVW) was used as the primary analytical method for MR. Sensitivity analyses were performed to detect horizontal pleiotropy and heterogeneity.<h4>Results</h4>Genetically predicted red blood cell distribution width, mean reticulocyte volume, and mean red blood cell volume were positively associated with VTE, with odds ratio (OR) of 1.002 [CI 1.000-1.003, <i>P</i> = 0.022), 1.003 (CI 1.001-1.004, <i>P</i> = 0.001, respectively)] and 1.001 (CI 1.000-1.002, <i>P</i> = 0.005). Genetically predicted monocyte count was negatively correlated with VTE, with OR = 0.998 (CI 0.996-0.999, <i>P</i> = 0.041).<h4>Conclusion</h4>Genetically liability to high- red blood cell distribution width, mean reticulocyte volume, mean red blood cell volume, and low monocyte count are associated with the higher risk of VTE. Targeting these factors might be a potential strategy to prevent VTE.2022-01-01T00:00:00Z20222025-04-26T07:33:26.985Z2025-04-06T12:19:03.575ZS-EPMC93045813587288910.3389/fcvm.2022.919640