{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["1511(1)"],"submitter":["Kallab M"],"pubmed_abstract":["We compare the focal structure-function correlation of structural measurements of peripapillary retinal nerve fiber layer thickness (RNFL-T) using optical coherence tomography (OCT), capillary density (CD) measurements using OCT-angiography (OCT-A), or a combination of both, with visual field deviation (VFD) in early to advanced glaucoma. Primary open angle glaucoma patients (n = 46, mean ± SD age: 67 ± 10 years; VF mean deviation: -10.41 ± 6.76 dB) were included in this cross-sectional study. We performed 30-2 standard automated perimetry OCT (3.5-mm diameter ring scan) and 15°×15° OCT-A (superficial vascular complex slab). Based on a nerve fiber trajectory model, each VF test spot was assigned to an OCT-A wedge and an OCT ring-sector. Two univariate linear models (M<sub>v</sub> and M<sub>t</sub> ) using either CD-based vascular (M<sub>v</sub> ) or RNFL-T-based thickness information (M<sub>t</sub> ) and one multivariate model using both (M<sub>v:t</sub> ) were compared in their associations with measured focal VFD, which were higher for the multivariate model M<sub>v:t</sub> (mean ± SD correlation coefficient: 0.710 ± 0.086) than for either nested model (0.627 ± 0.078 for M<sub>v</sub> and 0.578 ± 0.095 for M<sub>t</sub> ). Using a focal visual field approach, the combination of RNFL-T and CD showed better structure-function correlations than thickness or vascular information only."],"journal":["Annals of the New York Academy of Sciences"],"pagination":["133-141"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9305098"],"repository":["biostudies-literature"],"pubmed_title":["Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss."],"pmcid":["PMC9305098"],"pubmed_authors":["Schmetterer L","Wong D","Schlatter A","Schmidl D","Hommer N","Hirn C","Garhofer G","Kallab M","Findl O","Tan B","Chua J"],"additional_accession":[]},"is_claimable":false,"name":"Combining vascular and nerve fiber layer thickness measurements to model glaucomatous focal visual field loss.","description":"We compare the focal structure-function correlation of structural measurements of peripapillary retinal nerve fiber layer thickness (RNFL-T) using optical coherence tomography (OCT), capillary density (CD) measurements using OCT-angiography (OCT-A), or a combination of both, with visual field deviation (VFD) in early to advanced glaucoma. Primary open angle glaucoma patients (n = 46, mean ± SD age: 67 ± 10 years; VF mean deviation: -10.41 ± 6.76 dB) were included in this cross-sectional study. We performed 30-2 standard automated perimetry OCT (3.5-mm diameter ring scan) and 15°×15° OCT-A (superficial vascular complex slab). Based on a nerve fiber trajectory model, each VF test spot was assigned to an OCT-A wedge and an OCT ring-sector. Two univariate linear models (M<sub>v</sub> and M<sub>t</sub> ) using either CD-based vascular (M<sub>v</sub> ) or RNFL-T-based thickness information (M<sub>t</sub> ) and one multivariate model using both (M<sub>v:t</sub> ) were compared in their associations with measured focal VFD, which were higher for the multivariate model M<sub>v:t</sub> (mean ± SD correlation coefficient: 0.710 ± 0.086) than for either nested model (0.627 ± 0.078 for M<sub>v</sub> and 0.578 ± 0.095 for M<sub>t</sub> ). Using a focal visual field approach, the combination of RNFL-T and CD showed better structure-function correlations than thickness or vascular information only.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-26T13:00:53.306Z","creation":"2025-02-19T04:38:19.066Z"},"accession":"S-EPMC9305098","cross_references":{"pubmed":["35029314"],"doi":["10.1111/nyas.14732"]}}