biostudies-literatureUnknown12(33)Palierse EAdsorption of particles across interfaces has been proposed as a way to create adhesion between hydrogels and biological tissues. Here, we explore how this particle bridging approach can be applied to attach a soft polymer substrate to biological tissues, using bioresorbable and nanostructured hydroxyapatite-bioactive glass microparticles. For this, microparticles of aggregated flower-like hydroxyapatite and bioactive glass (HA-BG) were synthesized <i>via</i> a bioinspired route. A deposition technique using suspension spreading was developed to tune the coverage of HA-BG coatings at the surface of weakly cross-linked poly(beta-thioester) films. By varying the concentration of the deposited suspensions, we produced coatings having surface coverages ranging from 4% to 100% and coating densiRSC advances21079-21091https://www.ebi.ac.uk/biostudies/studies/S-EPMC9305725biostudies-literatureCoatings of hydroxyapatite-bioactive glass microparticles for adhesion to biological tissues.PMC9305725Palierse ENorvez SCorte LRoquart MfalseCoatings of hydroxyapatite-bioactive glass microparticles for adhesion to biological tissues.Adsorption of particles across interfaces has been proposed as a way to create adhesion between hydrogels and biological tissues. Here, we explore how this particle bridging approach can be applied to attach a soft polymer substrate to biological tissues, using bioresorbable and nanostructured hydroxyapatite-bioactive glass microparticles. For this, microparticles of aggregated flower-like hydroxyapatite and bioactive glass (HA-BG) were synthesized <i>via</i> a bioinspired route. A deposition technique using suspension spreading was developed to tune the coverage of HA-BG coatings at the surface of weakly cross-linked poly(beta-thioester) films. By varying the concentration of the deposited suspensions, we produced coatings having surface coverages ranging from 4% to 100% and coating densi2022-01-01T00:00:00Z2022 Jul2025-04-26T16:16:57.144Z2025-04-06T15:07:58.596ZS-EPMC93057253591983610.1039/d2ra02781j