{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tan Z"],"funding":["National Science Foundation of China","Natural Science Foundation of Shaanxi Province","Science Foundation for Distinguished Young Scholars of Shaanxi Province"],"pagination":["228"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9306173"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(1)"],"pubmed_abstract":["Background
Abnormal glycosylation in a variety of cancer types is involved in tumor progression and chemoresistance. Glycosyltransferase C1GALT1, the key enzyme in conversion of Tn antigen to T antigen, is involved in both physiological and pathological conditions. However, the mechanisms of C1GALT1 in enhancing oncogenic phenotypes and its regulatory effects via non-coding RNA are unclear.Methods
Abnormal expression of C1GALT1 and its products T antigen in human bladder cancer (BLCA) were evaluated with BLCA tissue, plasma samples and cell lines. Effects of C1GALT1 on migratory ability and proliferation were assessed in YTS-1 cells by transwell, CCK8 and colony formation assay in vitro and by mouse subcutaneous xenograft and trans-splenic metastasis models in vivo. Dysregu"],"journal":["Journal of experimental & clinical cancer research : CR"],"pubmed_title":["Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer."],"pmcid":["PMC9306173"],"funding_grant_id":["2021JC-39","31971211","81802654","32071274","2022JQ-205","2019JZ-22"],"pubmed_authors":["Cao L","Wu J","Lin S","Dong Z","Guan F","Zhou X","Zhao Z","Ye Z","Zhou Z","Jiang Y","Li X","Tan Z","Feng H","Liang L","Wang Y","Song Z"],"additional_accession":[]},"is_claimable":false,"name":"Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer.","description":"Background
Abnormal glycosylation in a variety of cancer types is involved in tumor progression and chemoresistance. Glycosyltransferase C1GALT1, the key enzyme in conversion of Tn antigen to T antigen, is involved in both physiological and pathological conditions. However, the mechanisms of C1GALT1 in enhancing oncogenic phenotypes and its regulatory effects via non-coding RNA are unclear.Methods
Abnormal expression of C1GALT1 and its products T antigen in human bladder cancer (BLCA) were evaluated with BLCA tissue, plasma samples and cell lines. Effects of C1GALT1 on migratory ability and proliferation were assessed in YTS-1 cells by transwell, CCK8 and colony formation assay in vitro and by mouse subcutaneous xenograft and trans-splenic metastasis models in vivo. Dysregu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-05T14:26:04.3Z","creation":"2024-11-13T05:50:37.508Z"},"accession":"S-EPMC9306173","cross_references":{"pubmed":["35864552"],"doi":["10.1186/s13046-022-02438-7"]}}