biostudies-literatureTan ZNational Science Foundation of ChinaNatural Science Foundation of Shaanxi ProvinceScience Foundation for Distinguished Young Scholars of Shaanxi Province228https://www.ebi.ac.uk/biostudies/studies/S-EPMC9306173biostudies-literatureUnknown41(1)<h4>Background</h4>Abnormal glycosylation in a variety of cancer types is involved in tumor progression and chemoresistance. Glycosyltransferase C1GALT1, the key enzyme in conversion of Tn antigen to T antigen, is involved in both physiological and pathological conditions. However, the mechanisms of C1GALT1 in enhancing oncogenic phenotypes and its regulatory effects via non-coding RNA are unclear.<h4>Methods</h4>Abnormal expression of C1GALT1 and its products T antigen in human bladder cancer (BLCA) were evaluated with BLCA tissue, plasma samples and cell lines. Effects of C1GALT1 on migratory ability and proliferation were assessed in YTS-1 cells by transwell, CCK8 and colony formation assay in vitro and by mouse subcutaneous xenograft and trans-splenic metastasis models in vivo. DysreguJournal of experimental & clinical cancer research : CRDysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer.PMC93061732021JC-393197121181802654320712742022JQ-2052019JZ-22Cao LWu JLin SDong ZGuan FZhou XZhao ZYe ZZhou ZJiang YLi XTan ZFeng HLiang LWang YSong ZfalseDysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer.<h4>Background</h4>Abnormal glycosylation in a variety of cancer types is involved in tumor progression and chemoresistance. Glycosyltransferase C1GALT1, the key enzyme in conversion of Tn antigen to T antigen, is involved in both physiological and pathological conditions. However, the mechanisms of C1GALT1 in enhancing oncogenic phenotypes and its regulatory effects via non-coding RNA are unclear.<h4>Methods</h4>Abnormal expression of C1GALT1 and its products T antigen in human bladder cancer (BLCA) were evaluated with BLCA tissue, plasma samples and cell lines. Effects of C1GALT1 on migratory ability and proliferation were assessed in YTS-1 cells by transwell, CCK8 and colony formation assay in vitro and by mouse subcutaneous xenograft and trans-splenic metastasis models in vivo. Dysregu2022-01-01T00:00:00Z2022 Jul2025-04-05T14:26:04.3Z2024-11-13T05:50:37.508ZS-EPMC93061733586455210.1186/s13046-022-02438-7