{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Brislin SJ"],"funding":["NIDA NIH HHS","NIAAA NIH HHS"],"pagination":["700-713"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9306410"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(4)"],"pubmed_abstract":["Abnormalities in responses to reward and loss are implicated in the etiology of antisocial behavior and psychopathic traits. While there is evidence for sex differences in neural response to reward and loss, it remains unclear how sex differences may moderate links between these neural responses and the phenotypic expression of antisocial behavior and psychopathic traits. This study examined sex differences in associations of neural response to reward and loss with antisocial personality symptoms and psychopathic traits. Functional neuroimaging data were collected during a monetary incentive delay task from 158 participants. Among males, during loss anticipation, activation in the left nucleus accumbens was negatively associated with antisocial behavior. Among females, during loss feedback, activation in the left nucleus accumbens and left amygdala was negatively associated with antisocial behavior. These results suggest that phenotypic sex differences in psychopathic traits and antisocial behavior may in part be attributable to different etiological pathways."],"journal":["Clinical psychological science : a journal of the Association for Psychological Science"],"pubmed_title":["Sex Moderates Reward- and Loss-Related Neural Correlates of Triarchic-Model Traits and Antisocial Behavior."],"pmcid":["PMC9306410"],"funding_grant_id":["K01 DA044270","R01 AA025790","T32 AA007477","K01 AA024804","R01 AA007065","K01 AA027558"],"pubmed_authors":["Cope LM","Zucker RA","Brislin SJ","Weigard AS","Hardee JE","Martz ME","Heitzeg MM"],"additional_accession":[]},"is_claimable":false,"name":"Sex Moderates Reward- and Loss-Related Neural Correlates of Triarchic-Model Traits and Antisocial Behavior.","description":"Abnormalities in responses to reward and loss are implicated in the etiology of antisocial behavior and psychopathic traits. While there is evidence for sex differences in neural response to reward and loss, it remains unclear how sex differences may moderate links between these neural responses and the phenotypic expression of antisocial behavior and psychopathic traits. This study examined sex differences in associations of neural response to reward and loss with antisocial personality symptoms and psychopathic traits. Functional neuroimaging data were collected during a monetary incentive delay task from 158 participants. Among males, during loss anticipation, activation in the left nucleus accumbens was negatively associated with antisocial behavior. Among females, during loss feedback, activation in the left nucleus accumbens and left amygdala was negatively associated with antisocial behavior. These results suggest that phenotypic sex differences in psychopathic traits and antisocial behavior may in part be attributable to different etiological pathways.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-04T10:47:34.802Z","creation":"2025-04-04T10:47:34.802Z"},"accession":"S-EPMC9306410","cross_references":{"pubmed":["35874917"],"doi":["10.1177/21677026211054780"]}}