{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(29)"],"submitter":["Paradis M"],"pubmed_abstract":["Dynamic contacts are formed between endoplasmic reticulum (ER) and mitochondria that enable the exchange of calcium and phospholipids. Disturbed contacts between ER and mitochondria impair mitochondrial dynamics and are a molecular hallmark of Parkinson's disease, which is also characterized by impaired complex I activity and dopaminergic neuron degeneration. Here, we analyzed the role of cysteine-rich with EGF-like domain (Creld), a poorly characterized risk gene for Parkinson's disease, in the regulation of mitochondrial dynamics and function. We found that loss of Creld leads to mitochondrial hyperfusion and reduced ROS signaling in <i>Drosophila melanogaster</i>, <i>Xenopus tropicalis</i>, and human cells. Creld fly mutants show differences in ER-mitochondria contacts and reduced respi"],"journal":["Science advances"],"pagination":["eabo0155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9307246"],"repository":["biostudies-literature"],"pubmed_title":["The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity."],"pmcid":["PMC9307246"],"pubmed_authors":["Meyer C","Paululat A","Jamitzky I","Sellin J","Paradis M","Kucharowski N","Kalinowski J","Bauer R","Thiele C","Maya Palacios SJ","Edwards Faret G","Stumpges B","Bulow MH"],"additional_accession":[]},"is_claimable":false,"name":"The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity.","description":"Dynamic contacts are formed between endoplasmic reticulum (ER) and mitochondria that enable the exchange of calcium and phospholipids. Disturbed contacts between ER and mitochondria impair mitochondrial dynamics and are a molecular hallmark of Parkinson's disease, which is also characterized by impaired complex I activity and dopaminergic neuron degeneration. Here, we analyzed the role of cysteine-rich with EGF-like domain (Creld), a poorly characterized risk gene for Parkinson's disease, in the regulation of mitochondrial dynamics and function. We found that loss of Creld leads to mitochondrial hyperfusion and reduced ROS signaling in <i>Drosophila melanogaster</i>, <i>Xenopus tropicalis</i>, and human cells. Creld fly mutants show differences in ER-mitochondria contacts and reduced respi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-22T11:28:21.31Z","creation":"2025-04-05T23:59:48.261Z"},"accession":"S-EPMC9307246","cross_references":{"pubmed":["35867795"],"doi":["10.1126/sciadv.abo0155"]}}