{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Li L"],"pubmed_abstract":["<i>Helicobacter pylori</i> (<i>H. pylori</i>) is the main pathogenic factor of gastric cancer, chronic gastritis, and other gastric diseases. It has been found that <i>Callicarpa nudiflora</i> (CN) as an air-dried leaf extract has a broad-spectrum antibacterial effect. This study aims to examine the effect of CN on <i>H. pylori</i>-infected GES-1 cells <i>in vitro</i> and elucidate its underlying mechanism by extracting active ingredients from air-dried leaves. GES-1 cells were cocultured with HPSS1 at MOI = 100 : 1 and treated with different concentrations of CN (100 and 200 <i>μ</i>g/ml). Results showed that CN can significantly reduce cellular LDH leakage and attenuate <i>H. pylori</i>-induced cell apoptosis and ROS production in GSE-1 cells, so as to protect gastric epithelial cells fr"],"journal":["The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale"],"pagination":["5469236"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9307406"],"repository":["biostudies-literature"],"pubmed_title":["The Anti-Inflammatory Effect of <i>Callicarpa nudiflora</i> Extract on <i>H. Pylori</i>-Infected GES-1 Cells through the Inhibition of ROS/NLRP3/Caspase-1/IL-1<i>β</i> Signaling Axis."],"pmcid":["PMC9307406"],"pubmed_authors":["Zhu X","Chen X","Li L","Bao B","Su X","Feng S","Chai X"],"additional_accession":[]},"is_claimable":false,"name":"The Anti-Inflammatory Effect of <i>Callicarpa nudiflora</i> Extract on <i>H. Pylori</i>-Infected GES-1 Cells through the Inhibition of ROS/NLRP3/Caspase-1/IL-1<i>β</i> Signaling Axis.","description":"<i>Helicobacter pylori</i> (<i>H. pylori</i>) is the main pathogenic factor of gastric cancer, chronic gastritis, and other gastric diseases. It has been found that <i>Callicarpa nudiflora</i> (CN) as an air-dried leaf extract has a broad-spectrum antibacterial effect. This study aims to examine the effect of CN on <i>H. pylori</i>-infected GES-1 cells <i>in vitro</i> and elucidate its underlying mechanism by extracting active ingredients from air-dried leaves. GES-1 cells were cocultured with HPSS1 at MOI = 100 : 1 and treated with different concentrations of CN (100 and 200 <i>μ</i>g/ml). Results showed that CN can significantly reduce cellular LDH leakage and attenuate <i>H. pylori</i>-induced cell apoptosis and ROS production in GSE-1 cells, so as to protect gastric epithelial cells fr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-05-29T19:03:35.692Z","creation":"2024-10-19T07:45:30.317Z"},"accession":"S-EPMC9307406","cross_references":{"pubmed":["35873363"],"doi":["10.1155/2022/5469236"]}}