biostudies-literatureUnknown2022Li L<i>Helicobacter pylori</i> (<i>H. pylori</i>) is the main pathogenic factor of gastric cancer, chronic gastritis, and other gastric diseases. It has been found that <i>Callicarpa nudiflora</i> (CN) as an air-dried leaf extract has a broad-spectrum antibacterial effect. This study aims to examine the effect of CN on <i>H. pylori</i>-infected GES-1 cells <i>in vitro</i> and elucidate its underlying mechanism by extracting active ingredients from air-dried leaves. GES-1 cells were cocultured with HPSS1 at MOI = 100 : 1 and treated with different concentrations of CN (100 and 200 <i>μ</i>g/ml). Results showed that CN can significantly reduce cellular LDH leakage and attenuate <i>H. pylori</i>-induced cell apoptosis and ROS production in GSE-1 cells, so as to protect gastric epithelial cells frThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale5469236https://www.ebi.ac.uk/biostudies/studies/S-EPMC9307406biostudies-literatureThe Anti-Inflammatory Effect of <i>Callicarpa nudiflora</i> Extract on <i>H. Pylori</i>-Infected GES-1 Cells through the Inhibition of ROS/NLRP3/Caspase-1/IL-1<i>β</i> Signaling Axis.PMC9307406Zhu XChen XLi LBao BSu XFeng SChai XfalseThe Anti-Inflammatory Effect of <i>Callicarpa nudiflora</i> Extract on <i>H. Pylori</i>-Infected GES-1 Cells through the Inhibition of ROS/NLRP3/Caspase-1/IL-1<i>β</i> Signaling Axis.<i>Helicobacter pylori</i> (<i>H. pylori</i>) is the main pathogenic factor of gastric cancer, chronic gastritis, and other gastric diseases. It has been found that <i>Callicarpa nudiflora</i> (CN) as an air-dried leaf extract has a broad-spectrum antibacterial effect. This study aims to examine the effect of CN on <i>H. pylori</i>-infected GES-1 cells <i>in vitro</i> and elucidate its underlying mechanism by extracting active ingredients from air-dried leaves. GES-1 cells were cocultured with HPSS1 at MOI = 100 : 1 and treated with different concentrations of CN (100 and 200 <i>μ</i>g/ml). Results showed that CN can significantly reduce cellular LDH leakage and attenuate <i>H. pylori</i>-induced cell apoptosis and ROS production in GSE-1 cells, so as to protect gastric epithelial cells fr2022-01-01T00:00:00Z20222025-05-29T19:03:35.692Z2024-10-19T07:45:30.317ZS-EPMC93074063587336310.1155/2022/5469236