{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li P"],"funding":["Key Technologies Research and Development Program","Natural Science Foundation of Beijing Municipality","National Natural Science Foundation of China"],"pagination":["48"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9308251"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>The single nucleotide polymorphisms (SNPs) in the fatty acid desaturases and elongases might associate with the endogenous synthesis of polyunsaturated fatty acids (PUFAs). However, the related epidemiological evidence is still conflicting. So we aimed to clearly evaluate the interactions between maternal DHA-rich n-3 PUFAs supplementation and the known 26 SNPs on the profiles of PUFAs in the colostrum using a Chinese birth cohort.<h4>Methods</h4>Totally, 1050 healthy mother-infant pairs were enrolled in this study at gestational 6-8 weeks when they established their pregnancy files at Fuxing Hospital affiliated to Capital Medical University in Beijing from January to December 2018. Meanwhile, their venous blood samples were obtained for DNA extraction to detect the geno"],"journal":["Nutrition & metabolism"],"pubmed_title":["Maternal DHA-rich n-3 PUFAs supplementation interacts with FADS genotypes to influence the profiles of PUFAs in the colostrum among Chinese Han population: a birth cohort study."],"pmcid":["PMC9308251"],"funding_grant_id":["82173524","2016YFC1000305","7174302"],"pubmed_authors":["Yan L","Fan X","Wang R","Qi K","Li P","Chen Y","Tang T","Song J","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Maternal DHA-rich n-3 PUFAs supplementation interacts with FADS genotypes to influence the profiles of PUFAs in the colostrum among Chinese Han population: a birth cohort study.","description":"<h4>Background</h4>The single nucleotide polymorphisms (SNPs) in the fatty acid desaturases and elongases might associate with the endogenous synthesis of polyunsaturated fatty acids (PUFAs). However, the related epidemiological evidence is still conflicting. So we aimed to clearly evaluate the interactions between maternal DHA-rich n-3 PUFAs supplementation and the known 26 SNPs on the profiles of PUFAs in the colostrum using a Chinese birth cohort.<h4>Methods</h4>Totally, 1050 healthy mother-infant pairs were enrolled in this study at gestational 6-8 weeks when they established their pregnancy files at Fuxing Hospital affiliated to Capital Medical University in Beijing from January to December 2018. Meanwhile, their venous blood samples were obtained for DNA extraction to detect the geno","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-03-16T16:58:41.621Z","creation":"2022-08-06T22:44:39.755Z"},"accession":"S-EPMC9308251","cross_references":{"pubmed":["35871074"],"doi":["10.1186/s12986-022-00683-3"]}}