{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fava A"],"funding":["NIH","Hopkins Lupus Cohort is funded by NIH","NIAMS NIH HHS"],"pagination":["2483-2493"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9308381"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["61(6)"],"pubmed_abstract":["<h4>Objectives</h4>Pure membranous (class V) LN is considered a less aggressive phenotype, but tissue fibrosis and chronic kidney disease may still develop. This study aimed to elucidate the prognostic value of a history of class switch in pure membranous LN.<h4>Methods</h4>We included LN patients with at least two clinically indicated kidney biopsies. New onset of end stage kidney disease (ESKD) was defined as estimated glomerular filtration rate <15 ml/min/1.73 m2, initiation of dialysis or kidney transplantation.<h4>Results</h4>Among 220 patients (542 biopsies), 199 (90%) were female, and 118 (54%) were African American, 59 (27%) Caucasian, with median age of 28 years at the first kidney biopsy. Patients with pure class V in a first biopsy converted to proliferative LN in 41% of cases. "],"journal":["Rheumatology (Oxford, England)"],"pubmed_title":["History of proliferative glomerulonephritis predicts end stage kidney disease in pure membranous lupus nephritis."],"pmcid":["PMC9308381"],"funding_grant_id":["AR 69572","R01 AR069572"],"pubmed_authors":["Fine D","Rosenberg A","Li J","Fenaroli P","Fava A","Petri M","Bagnasco S","Atta MG","Monroy-Trujillo J"],"additional_accession":[]},"is_claimable":false,"name":"History of proliferative glomerulonephritis predicts end stage kidney disease in pure membranous lupus nephritis.","description":"<h4>Objectives</h4>Pure membranous (class V) LN is considered a less aggressive phenotype, but tissue fibrosis and chronic kidney disease may still develop. This study aimed to elucidate the prognostic value of a history of class switch in pure membranous LN.<h4>Methods</h4>We included LN patients with at least two clinically indicated kidney biopsies. New onset of end stage kidney disease (ESKD) was defined as estimated glomerular filtration rate <15 ml/min/1.73 m2, initiation of dialysis or kidney transplantation.<h4>Results</h4>Among 220 patients (542 biopsies), 199 (90%) were female, and 118 (54%) were African American, 59 (27%) Caucasian, with median age of 28 years at the first kidney biopsy. Patients with pure class V in a first biopsy converted to proliferative LN in 41% of cases. ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-26T13:08:10.867Z","creation":"2025-04-26T13:08:10.867Z"},"accession":"S-EPMC9308381","cross_references":{"pubmed":["34664621"],"doi":["10.1093/rheumatology/keab775"]}}