biostudies-literatureFava ANIHHopkins Lupus Cohort is funded by NIHNIAMS NIH HHS2483-2493https://www.ebi.ac.uk/biostudies/studies/S-EPMC9308381biostudies-literatureUnknown61(6)<h4>Objectives</h4>Pure membranous (class V) LN is considered a less aggressive phenotype, but tissue fibrosis and chronic kidney disease may still develop. This study aimed to elucidate the prognostic value of a history of class switch in pure membranous LN.<h4>Methods</h4>We included LN patients with at least two clinically indicated kidney biopsies. New onset of end stage kidney disease (ESKD) was defined as estimated glomerular filtration rate <15 ml/min/1.73 m2, initiation of dialysis or kidney transplantation.<h4>Results</h4>Among 220 patients (542 biopsies), 199 (90%) were female, and 118 (54%) were African American, 59 (27%) Caucasian, with median age of 28 years at the first kidney biopsy. Patients with pure class V in a first biopsy converted to proliferative LN in 41% of cases. Rheumatology (Oxford, England)History of proliferative glomerulonephritis predicts end stage kidney disease in pure membranous lupus nephritis.PMC9308381AR 69572R01 AR069572Fine DRosenberg ALi JFenaroli PFava APetri MBagnasco SAtta MGMonroy-Trujillo JfalseHistory of proliferative glomerulonephritis predicts end stage kidney disease in pure membranous lupus nephritis.<h4>Objectives</h4>Pure membranous (class V) LN is considered a less aggressive phenotype, but tissue fibrosis and chronic kidney disease may still develop. This study aimed to elucidate the prognostic value of a history of class switch in pure membranous LN.<h4>Methods</h4>We included LN patients with at least two clinically indicated kidney biopsies. New onset of end stage kidney disease (ESKD) was defined as estimated glomerular filtration rate <15 ml/min/1.73 m2, initiation of dialysis or kidney transplantation.<h4>Results</h4>Among 220 patients (542 biopsies), 199 (90%) were female, and 118 (54%) were African American, 59 (27%) Caucasian, with median age of 28 years at the first kidney biopsy. Patients with pure class V in a first biopsy converted to proliferative LN in 41% of cases. 2022-01-01T00:00:00Z2022 May2025-04-26T13:08:10.867Z2025-04-26T13:08:10.867ZS-EPMC93083813466462110.1093/rheumatology/keab775