biostudies-literatureQing LNational Natural Science Foundation of China114https://www.ebi.ac.uk/biostudies/studies/S-EPMC9309451biostudies-literatureUnknown22(1)<h4>Background</h4>MUC1 is a type I transmembrane protein that plays an important role in tumor cell signal transduction. Although current studies have shown that MUC1 is upregulated in bladder cancer (BC), the specific mechanism is still unclear.<h4>Methods</h4>We performed expression analysis, gene set enrichment analysis, survival analysis, immune infiltration analysis, drug sensitivity analysis, and metabolism-related gene expression analysis on TCGA-BLCA, GES31684 and GSE13507.<h4>Results</h4>The expression of MUC1 in the tumor and lymphatic metastasis positive samples was significantly increased. Genes related to MUC1 expression were significantly enriched in immune response, ribosomes, exosomes, and energy metabolism. The results of the immune infiltration analysis showed that M1 maBMC urologyA prognosis marker MUC1 correlates with metabolism and drug resistance in bladder cancer: a bioinformatics research.PMC930945182160148Yang YDong ZLi QXu WQing LfalseA prognosis marker MUC1 correlates with metabolism and drug resistance in bladder cancer: a bioinformatics research.<h4>Background</h4>MUC1 is a type I transmembrane protein that plays an important role in tumor cell signal transduction. Although current studies have shown that MUC1 is upregulated in bladder cancer (BC), the specific mechanism is still unclear.<h4>Methods</h4>We performed expression analysis, gene set enrichment analysis, survival analysis, immune infiltration analysis, drug sensitivity analysis, and metabolism-related gene expression analysis on TCGA-BLCA, GES31684 and GSE13507.<h4>Results</h4>The expression of MUC1 in the tumor and lymphatic metastasis positive samples was significantly increased. Genes related to MUC1 expression were significantly enriched in immune response, ribosomes, exosomes, and energy metabolism. The results of the immune infiltration analysis showed that M1 ma2022-01-01T00:00:00Z2022 Jul2025-04-25T18:11:56.384Z2022-08-07T23:41:19.364ZS-EPMC93094513587974910.1186/s12894-022-01067-8