{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhao C"],"funding":["Natural Science Research Project of Anhui Universities","National Key R&D Program of China","Graduate Scientific Research Project of Anhui Universities"],"pagination":["15593258221115563"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9310246"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(3)"],"pubmed_abstract":["Traditional Chinese medicine (TCM) compounds have recently garnered attention for the regulation of immune cell infiltration and the prevention and treatment of Alzheimer's disease (AD). The Liuwei Dihuang Pill (LDP) has potential in this regard; however, its specific molecular mechanism currently remains unclear. Therefore, we adopted a bioinformatics approach to investigate the infiltration patterns of different types of immune cells in AD and explored the molecular mechanism of LDP intervention, with the aim of providing a new basis for improving the clinical immunotherapy of AD patients. We found that M1 macrophages showed significantly different degrees of infiltration between the hippocampal tissue samples of AD patients and healthy individuals. Four immune intersection targets of LD"],"journal":["Dose-response : a publication of International Hormesis Society"],"pubmed_title":["Bioinformatics-Based Approach for Exploring the Immune Cell Infiltration Patterns in Alzheimer's Disease and Determining the Intervention Mechanism of Liuwei Dihuang Pill."],"pmcid":["PMC9310246"],"funding_grant_id":["yjs20210476","kj2021a0547","2018YFC1704400","2018YFC1704404"],"pubmed_authors":["Jiang Z","Dong T","Tian L","Tang L","Zhao C","Zhou A"],"additional_accession":[]},"is_claimable":false,"name":"Bioinformatics-Based Approach for Exploring the Immune Cell Infiltration Patterns in Alzheimer's Disease and Determining the Intervention Mechanism of Liuwei Dihuang Pill.","description":"Traditional Chinese medicine (TCM) compounds have recently garnered attention for the regulation of immune cell infiltration and the prevention and treatment of Alzheimer's disease (AD). The Liuwei Dihuang Pill (LDP) has potential in this regard; however, its specific molecular mechanism currently remains unclear. Therefore, we adopted a bioinformatics approach to investigate the infiltration patterns of different types of immune cells in AD and explored the molecular mechanism of LDP intervention, with the aim of providing a new basis for improving the clinical immunotherapy of AD patients. We found that M1 macrophages showed significantly different degrees of infiltration between the hippocampal tissue samples of AD patients and healthy individuals. Four immune intersection targets of LD","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul-Sep","modification":"2025-04-04T18:57:31.472Z","creation":"2024-11-21T01:25:31.227Z"},"accession":"S-EPMC9310246","cross_references":{"pubmed":["35898725"],"doi":["10.1177/15593258221115563"]}}