biostudies-literatureLi XShenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research InstitutionsTechnology Innovation Commission1350https://www.ebi.ac.uk/biostudies/studies/S-EPMC9312019biostudies-literatureUnknown11(7)(1) Background: With unknown causes and no effective treatment available, Alzheimer's disease (AD) places enormous pressure on families and society. Our previous study had shown that Ebselen at a high concentration (10.94 μM) improved the cognition of triple-transgenic AD (3×Tg-AD) mice and alleviated the related pathological indicators but showed toxicity to the mice. Here, we dedicated to study the therapeutic effect and molecular mechanism of Ebselen at a much lower concentration on 3×Tg-AD mice. (2) Methods: Various behavioral experiments were applied to detect the behavioral ability of mice. Western blot, thioflavin T staining and a transmission electron microscope were used to evaluate the pathology of AD mice. The mitochondrial membrane potential and respiration were assessed with tAntioxidants (Basel, Switzerland)Ebselen Interferes with Alzheimer's Disease by Regulating Mitochondrial Function.PMC93120192021SHIBS0003JCYJ20200109110001818JCYJ20180507182417779Xiong YLi XLe LLian JPeng FWang CShi QLiu QDu XXu HWu GfalseEbselen Interferes with Alzheimer's Disease by Regulating Mitochondrial Function.(1) Background: With unknown causes and no effective treatment available, Alzheimer's disease (AD) places enormous pressure on families and society. Our previous study had shown that Ebselen at a high concentration (10.94 μM) improved the cognition of triple-transgenic AD (3×Tg-AD) mice and alleviated the related pathological indicators but showed toxicity to the mice. Here, we dedicated to study the therapeutic effect and molecular mechanism of Ebselen at a much lower concentration on 3×Tg-AD mice. (2) Methods: Various behavioral experiments were applied to detect the behavioral ability of mice. Western blot, thioflavin T staining and a transmission electron microscope were used to evaluate the pathology of AD mice. The mitochondrial membrane potential and respiration were assessed with t2022-01-01T00:00:00Z2022 Jul2025-05-31T22:26:06.06Z2022-08-05T06:28:16.804ZS-EPMC93120193588384110.3390/antiox11071350