{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vergori A"],"funding":["Ministero della Salute"],"pagination":["1575"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9316052"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(7)"],"pubmed_abstract":["The main aim of this study was to describe the clinical and immunological outcomes, as well as the inflammatory profile, of patients with advanced HIV in an assisted-living facility in which an outbreak of SARS-CoV-2 occurred. SARS-CoV-2 humoral and specific T-cell response were analyzed in patients with HIV infection and COVID-19; as a secondary objective of the analysis, levels of the inflammatory markers (IL-1β, IL-6, IL-8, and TNFα) were tested in the HIV/COVID-19 group, in HIV-positive patients without COVID-19, and in HIV-negative patients with mild/moderate COVID-19. Antibody kinetics and ability to neutralize SARS-CoV-2 were evaluated by ELISA assay, as well as the inflammatory cytokines; SARS-CoV-2 specific T-cell response was quantified by ELISpot assay. Mann−Whitney or Kruskal−W"],"journal":["Viruses"],"pubmed_title":["SARS-CoV-2 Specific Immune Response and Inflammatory Profile in Advanced HIV-Infected Persons during a COVID-19 Outbreak."],"pmcid":["PMC9316052"],"funding_grant_id":["Line 1 and 2 - Ricerca Corrente","COVID-2020-12371675"],"pubmed_authors":["Gagliardini R","Boschini A","Piselli P","Matusali G","Angeli L","Vergori A","Agrati C","Castilletti C","Maeurer M","Antinori A","Girardi E","Notari S","Tartaglia E","Lorenzini P","Cimini E","Boschi A","Colavita F"],"additional_accession":[]},"is_claimable":false,"name":"SARS-CoV-2 Specific Immune Response and Inflammatory Profile in Advanced HIV-Infected Persons during a COVID-19 Outbreak.","description":"The main aim of this study was to describe the clinical and immunological outcomes, as well as the inflammatory profile, of patients with advanced HIV in an assisted-living facility in which an outbreak of SARS-CoV-2 occurred. SARS-CoV-2 humoral and specific T-cell response were analyzed in patients with HIV infection and COVID-19; as a secondary objective of the analysis, levels of the inflammatory markers (IL-1β, IL-6, IL-8, and TNFα) were tested in the HIV/COVID-19 group, in HIV-positive patients without COVID-19, and in HIV-negative patients with mild/moderate COVID-19. Antibody kinetics and ability to neutralize SARS-CoV-2 were evaluated by ELISA assay, as well as the inflammatory cytokines; SARS-CoV-2 specific T-cell response was quantified by ELISpot assay. Mann−Whitney or Kruskal−W","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-18T20:34:34.871Z","creation":"2024-10-19T12:10:12.011Z"},"accession":"S-EPMC9316052","cross_references":{"pubmed":["35891555"],"doi":["10.3390/v14071575"]}}