biostudies-literatureMaier BFrench Health Ministry598https://www.ebi.ac.uk/biostudies/studies/S-EPMC9317065biostudies-literatureUnknown23(1)<h4>Background</h4>Hypotension and blood pressure (BP) variability during endovascular therapy (EVT) for acute ischemic stroke (AIS) due to an anterior large vessel occlusion (LVO) is associated with worse outcomes. However, the optimal BP threshold during EVT is still unknown given the lack of randomized controlled evidence. We designed the DETERMINE trial to assess whether an individualized BP management during EVT could achieve better functional outcomes compared to a standard BP management.<h4>Methods</h4>The DETERMINE trial is a multicenter, prospective, randomized, controlled, open-label, blinded endpoint clinical trial (PROBE design). AIS patients with a proximal anterior LVO are randomly assigned, in a 1:1 ratio, to an experimental arm in which mean arterial pressure (MAP) is maintTrialsEffect of an individualized versus standard blood pressure management during mechanical thrombectomy for anterior ischemic stroke: the DETERMINE randomized controlled trial.PMC9317065AOR19069Balanca BAnxionnat RHumbertjean LSeners PDi Roio CBodonian CPioche PARoudies SHMartin JPiotin MRichard SNghe-Mann MCBourst POmarjee MYahia YALe Cossec CAlb LBricout NFogang AClariot SGuyot ACarrillon RTavernier BLteif EMasgrau AGemanar ALestrade VEscalard SHebert SGrobost RFerri EDETERMINE InvestigatorsLevrier KCognard CLapergue BShaffii ALiao LDorison MNaboulsi EClarencon FSenechal MDegos VJulean GZhu FMerat SMione GBlanc RZerroug ALak CADjarallah ADa Costa IMoreno RLe Bigot PCalviere LJulie DBouchier BVoicu MBoissy CMazighi MYavchitz ASmajda SGuy SGeorges VBraun MBechiri FGeeraerts TOlivot JMTabarna AAudibert GMophawe OSchiava LDPlanel SReitter MPodar ISabben CRousset JChabert ELe Guen MLe Garrec FEnvain DLacour JCDelvoye FThion LAGory BMarcou ABelhadj-Tahar NMoures JMCosserant BDerelle ALAmarouche ABracard SAppourchaux PCammas TGayat EDesilles JPPommier MMasson ADevys JMFerrier AGras SDubois MCBegard MBrezeanu MBoussemart PPrevost EBoursin PSchmitt EBellet JRedjem HDouarinou MFroucht-Hirsch SMaier BBapteste LChabanne RfalseEffect of an individualized versus standard blood pressure management during mechanical thrombectomy for anterior ischemic stroke: the DETERMINE randomized controlled trial.<h4>Background</h4>Hypotension and blood pressure (BP) variability during endovascular therapy (EVT) for acute ischemic stroke (AIS) due to an anterior large vessel occlusion (LVO) is associated with worse outcomes. However, the optimal BP threshold during EVT is still unknown given the lack of randomized controlled evidence. We designed the DETERMINE trial to assess whether an individualized BP management during EVT could achieve better functional outcomes compared to a standard BP management.<h4>Methods</h4>The DETERMINE trial is a multicenter, prospective, randomized, controlled, open-label, blinded endpoint clinical trial (PROBE design). AIS patients with a proximal anterior LVO are randomly assigned, in a 1:1 ratio, to an experimental arm in which mean arterial pressure (MAP) is maint2022-01-01T00:00:00Z2022 Jul2026-05-28T00:02:48.596Z2022-08-06T14:47:07.279ZS-EPMC93170653588318010.1186/s13063-022-06538-9