biostudies-literatureUnknown13(7)Perik-Zavodskii RAutoimmune regulator (AIRE) is a multifunctional protein that is capable of inducing tissue-specific antigens' (TSAs) gene expression, a key event in the induction of self-tolerance, that is usually expressed and functions in the thymus. However, its expression has been detected outside the thymus and cells expressing the gene have been named extra-thymic <i>AIRE</i> expressing cells (eTACs). Here, we discuss the finding of <i>AIRE</i> and TSAs gene expression in CD71+ cells from human fetal liver parenchyma, which are mostly represented by CD71+ erythroid cells.Genes1278https://www.ebi.ac.uk/biostudies/studies/S-EPMC9317677biostudies-literatureHuman Fetal Liver Parenchyma CD71+ Cells Have AIRE and Tissue-Specific Antigen Gene Expression.PMC9317677Perik-Zavodskii RZaitsev KAlrhmoun SVolynets MShevchenko YSennikov SPerik-Zavodskaya OfalseHuman Fetal Liver Parenchyma CD71+ Cells Have AIRE and Tissue-Specific Antigen Gene Expression.Autoimmune regulator (AIRE) is a multifunctional protein that is capable of inducing tissue-specific antigens' (TSAs) gene expression, a key event in the induction of self-tolerance, that is usually expressed and functions in the thymus. However, its expression has been detected outside the thymus and cells expressing the gene have been named extra-thymic <i>AIRE</i> expressing cells (eTACs). Here, we discuss the finding of <i>AIRE</i> and TSAs gene expression in CD71+ cells from human fetal liver parenchyma, which are mostly represented by CD71+ erythroid cells.2022-01-01T00:00:00Z2022 Jul2025-04-22T09:51:55.373Z2025-04-05T23:15:27.321ZS-EPMC93176773588606010.3390/genes13071278